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FGF9 is required for Purkinje cell development and function in the cerebellum
iScience ( IF 4.6 ) Pub Date : 2024-01-26 , DOI: 10.1016/j.isci.2024.109039
Ping He 1 , Shuting Zhong 1 , Shuaijun Lin 1 , Zhiyan Xia 1 , Liqing Wang 1 , Yuhe Han 1 , Di Xu 2 , Shuping Hu 1 , Xiaokun Li 1 , Peijun Li 2, 3 , Cong Wang 1
iScience ( IF 4.6 ) Pub Date : 2024-01-26 , DOI: 10.1016/j.isci.2024.109039
Ping He 1 , Shuting Zhong 1 , Shuaijun Lin 1 , Zhiyan Xia 1 , Liqing Wang 1 , Yuhe Han 1 , Di Xu 2 , Shuping Hu 1 , Xiaokun Li 1 , Peijun Li 2, 3 , Cong Wang 1
Affiliation
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Fibroblast growth factor 9 (FGF9) is a member of the fibroblast growth factor family, which is widely expressed in the central nervous system (CNS). It has been reported that deletion of FGF9 leads to defects in cerebellum development, including Purkinje cell defect. However, it is not clear how FGF9 regulating cerebellar development remains to be determined. Our results showed that in addition to disrupt Bergmann fiber scaffold formation and granule neuron migration, deletion of neuronal FGF9 led to ataxia defects. It affected development and function of Purkinje cells, and also changed the action potential threshold and excitation frequency. Mechanistically, depletion of FGF9 significantly changed neurotransmitter contents in Purkinje cells and led to preferential increase in inflammation, even downregulation in ERK signaling. Together, the data demonstrate that neuronal FGF9 is required for the development and function of Purkinje cells in the cerebellum. Insufficient FGF9 during cerebellum development will cause ataxia defects.
中文翻译：
FGF9 是小脑中浦肯野细胞发育和功能所必需的
成纤维细胞生长因子 9 （FGF9） 是成纤维细胞生长因子家族的一员，在中枢神经系统 （CNS） 中广泛表达。据报道，FGF9 缺失导致小脑发育缺陷，包括浦肯野细胞缺陷。然而，目前尚不清楚 FGF9 如何调节小脑发育仍有待确定。我们的结果表明，除了破坏 Bergmann 纤维支架形成和颗粒神经元迁移外，神经元 FGF9 的缺失还导致共济失调缺陷。它影响浦肯野细胞的发育和功能，也改变了动作电位阈值和兴奋频率。从机制上讲，FGF9 的耗竭显着改变了浦肯野细胞中的神经递质含量，并导致炎症优先增加，甚至 ERK 信号传导下调。总之，数据表明神经元 FGF9 是小脑中浦肯野细胞发育和功能所必需的。小脑发育过程中 FGF9 不足会导致共济失调缺陷。
更新日期：2024-01-26
中文翻译：
FGF9 是小脑中浦肯野细胞发育和功能所必需的
成纤维细胞生长因子 9 （FGF9） 是成纤维细胞生长因子家族的一员，在中枢神经系统 （CNS） 中广泛表达。据报道，FGF9 缺失导致小脑发育缺陷，包括浦肯野细胞缺陷。然而，目前尚不清楚 FGF9 如何调节小脑发育仍有待确定。我们的结果表明，除了破坏 Bergmann 纤维支架形成和颗粒神经元迁移外，神经元 FGF9 的缺失还导致共济失调缺陷。它影响浦肯野细胞的发育和功能，也改变了动作电位阈值和兴奋频率。从机制上讲，FGF9 的耗竭显着改变了浦肯野细胞中的神经递质含量，并导致炎症优先增加，甚至 ERK 信号传导下调。总之，数据表明神经元 FGF9 是小脑中浦肯野细胞发育和功能所必需的。小脑发育过程中 FGF9 不足会导致共济失调缺陷。
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