Chemical and biological characterization of vaccine adjuvant QS-21 produced via plant cell culture,iScience

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Chemical and biological characterization of vaccine adjuvant QS-21 produced via plant cell culture
iScience ( IF 4.6 ) Pub Date : 2024-01-26 , DOI: 10.1016/j.isci.2024.109006
Xiangmin Lv ₁ , Jesse Martin ₁ , Heather Hoover ₁ , Bishnu Joshi ₁ , Margaret Wilkens ₁ , David A Ullisch ₂ , Thomas Leibold ₂ , John S Juchum ₃ , Sanket Revadkar ₁ , Barbara Kalinovska ₁ , Justin Keith ₁ , Adam Truby ₄ , Gui Liu ₅ , Elaine Sun ₁ , John Haserick ₁ , Jon DeGnore ₁ , Joseph Conolly ₁ , Adrian V S Hill ₄ , John Baldoni ₅ , Charlotte Kensil ₅ , Dan Levey ₁ , Alexandra J Spencer _{4,

6} , Gilbert Gorr ₂ , Mark Findeis ₁ , Antoine Tanne ₅

Affiliation

Many vaccines, including those using recombinant antigen subunits, rely on adjuvant(s) to enhance the efficacy of the host immune responses. Among the few adjuvants clinically approved, QS-21, a saponin-based immunomodulatory molecule isolated from the tree bark of (QS) is used in complex formulations in approved effective vaccines. High demand of the QS raw material as well as manufacturing scalability limitation has been barriers here. We report for the first-time successful plant cell culture production of QS-21 having structural, chemical, and biologic, properties similar to the bark extracted product. These data ensure QS-21 and related saponins are broadly available and accessible to drug developers.

中文翻译：

植物细胞培养产生的疫苗佐剂 QS-21 的化学和生物学表征

许多疫苗，包括使用重组抗原亚单位的疫苗，都依赖于佐剂来增强宿主免疫反应的功效。在临床批准的少数佐剂中，QS-21 是一种从（QS）树皮中分离的基于皂苷的免疫调节分子，用于已批准有效疫苗的复杂配方。对 QS 原材料的高需求以及制造可扩展性的限制一直是这里的障碍。我们首次成功报道了 QS-21 的植物细胞培养生产，其结构、化学和生物特性与树皮提取产品相似。这些数据确保 QS-21 和相关皂苷广泛可用，并为药物开发人员所用。

更新日期：2024-01-26

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