OSMAC Strategy: A promising way to explore microbial cyclic peptides,European Journal of Medicinal Chemistry

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OSMAC Strategy: A promising way to explore microbial cyclic peptides
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2024-01-26 , DOI: 10.1016/j.ejmech.2024.116175
Yu Zhang ₁ , Li Feng ₁ , Xinya Hemu ₁ , Ning-Hua Tan ₁ , Zhe Wang ₁

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Microbial secondary metabolites are pivotal for the development of novel drugs. However, conventional culture techniques, have left a vast array of unexpressed biosynthetic gene clusters (BGCs) in microorganisms, hindering the discovery of metabolites with distinct structural features and diverse biological functions. To address this limitation, several innovative strategies have been emerged. The “One Strain Many Compounds” (OSMAC) strategy, which involves altering microbial culture conditions, has proven to be particularly effective in mining numerous novel secondary metabolites for the past few years. Among these, microbial cyclic peptides stand out. These peptides often comprise rare amino acids, unique chemical structures, and remarkable biological function. With the advancement of the OSMAC strategy, a plethora of new cyclic peptides have been identified from diverse microbial genera. This work reviews the progress in mining novel compounds using the OSMAC strategy and the applications of this strategy in discovering 284 microbial cyclic peptides from 63 endophytic strains, aiming to offer insights for the further explorations into novel active cyclic peptides.

中文翻译：

OSMAC 策略：探索微生物环肽的一种有前景的方法

微生物次生代谢产物对于新药的开发至关重要。然而，传统的培养技术在微生物中留下了大量未表达的生物合成基因簇（BGC），阻碍了具有独特结构特征和多样化生物学功能的代谢物的发现。为了解决这一限制，出现了几种创新策略。 “一株多化合物”（OSMAC）策略涉及改变微生物培养条件，已被证明在过去几年中在挖掘大量新型次生代谢物方面特别有效。其中，微生物环肽脱颖而出。这些肽通常包含稀有氨基酸、独特的化学结构和显着的生物学功能。随着 OSMAC 策略的进展，从不同的微生物属中鉴定出了大量新的环肽。该工作综述了利用OSMAC策略挖掘新型化合物的进展以及该策略在从63个内生菌株中发现284种微生物环肽中的应用，旨在为进一步探索新型活性环肽提供参考。

更新日期：2024-01-26

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