Five undescribed eudesmane methyl esters (1−5), three undescribed eudesmane-12,6-olides (6−8), and 21 known analogues (9−29) were isolated from the aerial part of Artemisia princeps Pamp. Their structures were established by detailed analysis of the NMR and HRESIMS data. The absolute configurations of 1−8 were determined based on single-crystal X-ray diffraction analysis and ECD calculations. Moreover, the inhibitory effects on LPS-induced NO production in BV-2 microglial cells of all the isolated compounds were assessed. Except for compounds 2, 4, 10, and 11, the others showed significant inhibitory activities, with IC₅₀ values of 0.73–18.66 μM, wherein the potential structure-activity relationship was also discussed.

从蒿的地上部分分离出5 种未描述的桉烷甲酯 ( 1 − 5 )、三种未描述的 12,6-烯醇酯 ( 6 − 8 ) 和 21 种已知类似物 ( 9 − 29 ) 。它们的结构是通过对 NMR 和 HRESIMS 数据的详细分析而确定的。基于单晶X射线衍射分析和ECD计算确定了1 – 8的绝对构型。此外，还评估了所有分离化合物对 BV-2 小胶质细胞中 LPS 诱导的 NO 产生的抑制作用。除化合物2、4、10和11外，其他化合物均表现出显着的抑制活性，IC ₅₀值为0.73-18.66 μM，其中潜在的构效关系也被讨论。