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Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Colocalization of Nanoparticle-Cargo in the Skin and Enhancement of Sonodynamic Efficacy
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2024-01-23 , DOI: 10.1021/acsanm.3c04675 Xinxing Sun 1 , Qiuyue Wang 1 , Hongyang Bao 1 , Yitong Liu 2 , Sicheng Yao 1 , Mingming Li 1 , Naiying Chen 1 , Yang Chen 1
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2024-01-23 , DOI: 10.1021/acsanm.3c04675 Xinxing Sun 1 , Qiuyue Wang 1 , Hongyang Bao 1 , Yitong Liu 2 , Sicheng Yao 1 , Mingming Li 1 , Naiying Chen 1 , Yang Chen 1
Affiliation
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Sonodynamic therapy (SDT) is a novel therapeutic modality that is effective for the noninvasive treatment of dermatological diseases. As a ubiquitous large class of sonosensitizers, however, porphyrins suffer from poor skin permeability and the inefficient generation of reactive oxygen species. Herein, different-sized porphyrinic metal–organic frameworks (MOFs), PCN-224 (90, 125, and 200 nm), were developed via the coordination of tetra-kis(4-carboxyphenyl) porphyrin (TCPP) and the metal zirconium to enhance the local delivery of porphyrins, and fluorescent sonosensitizers (methylene blue or rhodamine 6G) were further incorporated to improve the sonodynamic effect, as well as to visualize the delivery of PCN-224 and its cargo. The skin penetration of PCN-224 was found to be increased with the reduction of particle size, and all three-sized samples could overcome the barrier of stratum corneum, even achieving the dermis of the porcine skin. Both intercellular and follicular pathways were noticed for three-sized PCN-224, while the follicular one played a more significant role in the penetration of the smallest PCN-224. The intact nanoparticles were found in the skin. At the initial stage, the nanoparticle and its cargo penetrated the skin as an intact entity, while the encapsulated rhodamine 6G was slowly released to the microenvironment of the skin from the nanoparticle with the prolongation of application. The combination of PCN-224 and methylene blue could increase the acoustically triggered generation of 1O2, distinctly boosting the lethal effect against the cancerous cell. Collectively, the study revealed the feasibility of PCN-224 for topical use, suggested an innovative method to enhance the sonodynamic effect, and proposed a possible mechanism for skin drug delivery of MOFs.
中文翻译：
卟啉金属有机框架 PCN-224 纳米颗粒用于纳米颗粒-货物在皮肤中的共定位并增强声动力功效
声动力疗法（SDT）是一种新型的治疗方式，可有效无创治疗皮肤病。然而，作为一类普遍存在的声敏剂，卟啉存在皮肤渗透性差和活性氧生成效率低的问题。在此，通过四（4-羧基苯基）卟啉（TCPP）和金属锆的配位开发了不同尺寸的卟啉金属有机框架（MOF）PCN-224（90、125和200 nm）增强卟啉的局部递送，并进一步掺入荧光声敏剂（亚甲蓝或罗丹明 6G）以改善声动力效应，并使 PCN-224 及其货物的递送可视化。研究发现PCN-224的皮肤渗透性随着粒径的减小而增加，三种尺寸的样品均能克服角质层的屏障，甚至到达猪皮肤的真皮层。三种尺寸的 PCN-224 均观察到细胞间和滤泡途径，而滤泡途径在最小 PCN-224 的渗透中发挥更重要的作用。在皮肤中发现了完整的纳米颗粒。在初始阶段，纳米颗粒及其货物作为完整的实体渗透皮肤，而随着使用时间的延长，封装的罗丹明6G从纳米颗粒中缓慢释放到皮肤的微环境中。 PCN-224和亚甲蓝的组合可以增加声学触发的1 O 2的产生，明显增强对癌细胞的致命作用。总的来说，该研究揭示了 PCN-224 局部使用的可行性，提出了一种增强声动力效应的创新方法，并提出了 MOF 皮肤药物输送的可能机制。
更新日期：2024-01-23
中文翻译：
卟啉金属有机框架 PCN-224 纳米颗粒用于纳米颗粒-货物在皮肤中的共定位并增强声动力功效
声动力疗法（SDT）是一种新型的治疗方式，可有效无创治疗皮肤病。然而，作为一类普遍存在的声敏剂，卟啉存在皮肤渗透性差和活性氧生成效率低的问题。在此，通过四（4-羧基苯基）卟啉（TCPP）和金属锆的配位开发了不同尺寸的卟啉金属有机框架（MOF）PCN-224（90、125和200 nm）增强卟啉的局部递送，并进一步掺入荧光声敏剂（亚甲蓝或罗丹明 6G）以改善声动力效应，并使 PCN-224 及其货物的递送可视化。研究发现PCN-224的皮肤渗透性随着粒径的减小而增加，三种尺寸的样品均能克服角质层的屏障，甚至到达猪皮肤的真皮层。三种尺寸的 PCN-224 均观察到细胞间和滤泡途径，而滤泡途径在最小 PCN-224 的渗透中发挥更重要的作用。在皮肤中发现了完整的纳米颗粒。在初始阶段，纳米颗粒及其货物作为完整的实体渗透皮肤，而随着使用时间的延长，封装的罗丹明6G从纳米颗粒中缓慢释放到皮肤的微环境中。 PCN-224和亚甲蓝的组合可以增加声学触发的1 O 2的产生，明显增强对癌细胞的致命作用。总的来说，该研究揭示了 PCN-224 局部使用的可行性，提出了一种增强声动力效应的创新方法，并提出了 MOF 皮肤药物输送的可能机制。
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