Stimulus-Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy,Advanced Science

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Stimulus-Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy
Advanced Science ( IF 14.3 ) Pub Date : 2024-01-25 , DOI: 10.1002/advs.202309388
Fuzhen Hu ₁ , Jia Huang ₂ , Tiejun Bing ₃ , Wenlong Mou ₁ , Duo Li ₂ , Hanchen Zhang ₄ , Yang Chen ₅ , Qionghua Jin _{1,

6} , Yingjie Yu ₇ , Zhiying Yang ₂

Affiliation

Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy of cuproptosis remains limited by the poor delivery efficiency of copper ion carriers. Herein, copper complex nanoparticles (denoted as Cu(I) NP) are developed that can efficiently deliver copper complex into cancer cells to induce cuproptosis. Cu(I) NP demonstrate stimulus-responsive release of copper complexes, which results in mitochondrial dysfunction and promotes the aggregation of lipoylated dihydrolipoamide S-acetyltransferase (DLAT), leading to cuproptosis. Notably, Cu(I) NP not only induce cuproptosis, but also elicit robust immune responses to suppress tumor growth. Overall, this study provides a promising strategy for cuproptosis-based cancer therapy.

中文翻译：

刺激响应性铜复合纳米颗粒诱导铜垂下以增强癌症免疫疗法

铜中毒是一种新兴的程序性细胞死亡形式，在癌症治疗中受到了极大的关注。然而，铜凋亡的功效仍然受到铜离子载体递送效率差的限制。在此，开发了铜复合物纳米粒子（表示为 Cu(I) NP），它可以有效地将铜复合物递送到癌细胞中以诱导铜凋亡。 Cu(I) NP 表现出铜复合物的刺激响应性释放，导致线粒体功能障碍并促进硫辛酰化二氢硫辛酰胺 S-乙酰转移酶 (DLAT) 的聚集，从而导致铜凋亡。值得注意的是，Cu(I) NP 不仅能诱导铜凋亡，还能引发强大的免疫反应来抑制肿瘤生长。总体而言，这项研究为基于铜凋亡的癌症治疗提供了一种有前景的策略。

更新日期：2024-01-25

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