Mortality and morbidity of Acute Respiratory Distress Syndrome (ARDS) are largely unaltered. A possible new approach to treatment of ARDS is offered by the discovery of inflammatory subphenotypes. In an ovine model of ARDS phenotypes, matching key features of the human subphenotypes, we provide an imaging characterization using computer tomography (CT). Nine animals were randomized into (a) OA (oleic acid, hypoinflammatory; n = 5) and (b) OA-LPS (oleic acid and lipopolysaccharides, hyperinflammatory; n = 4). 48 h after ARDS induction and anti-inflammatory treatment, CT scans were performed at high (H) and then low (L) airway pressure. After CT, the animals were euthanized and lung tissue was collected. OA-LPS showed a higher air fraction and OA a higher tissue fraction, resulting in more normally aerated lungs in OA-LPS in contrast to more non-aerated lung in OA. The change in lung and air volume between H and L was more accentuated in OA-LPS, indicating a higher recruitment potential. Strain was higher in OA, indicating a higher level of lung damage, while the amount of lung edema and histological lung injury were largely comparable. Anti-inflammatory treatment might be beneficial in terms of overall ventilated lung portion and recruitment potential, especially in the OA-LPS group.

急性呼吸窘迫综合征 （ARDS） 的死亡率和发病率基本没有改变。炎症亚表型的发现提供了一种可能的治疗 ARDS 的新方法。在 ARDS 表型的绵羊模型中，匹配人类亚型的关键特征，我们提供了使用计算机断层扫描 （CT） 的成像特征。将 9 只动物随机分为 （a） OA （油酸，低炎症;n = 5） 和 （b） OA-LPS （油酸和脂多糖，过度炎症;n = 4）。ARDS 诱导和抗炎治疗后 48 h，在高 （H） 和低 （L） 气道压力下进行 CT 扫描。CT 后，对动物实施安乐死并收集肺组织。OA-LPS 显示较高的空气分数，OA 显示较高的组织分数，导致 OA-LPS 中的肺通气更正常，而 OA 中的肺更不充气。OA-LPS 中 H 和 L 之间的肺和气量变化更为明显，表明募集潜力更高。OA 患者的应变较高，表明肺损伤水平较高，而肺水肿和组织学肺损伤的数量在很大程度上相当。抗炎治疗可能对整体通气肺部分和募集潜力有益，尤其是在 OA-LPS 组中。