<br>在锌基引导骨生成膜上制备纳米级镁/铜金属有机框架，以增强成骨、血管生成和抑菌性能,ACS Applied Materials & Interfaces

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在锌基引导骨生成膜上制备纳米级镁/铜金属有机框架，以增强成骨、血管生成和抑菌性能
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2024-01-24 , DOI: 10.1021/acsami.3c16970
Kai Chen _{1,

2} , Yifan Wang ₁ , Hongyan Tang ₁ , Xufeng Niu ₁ , Hongtao Yang ₃ , Yanjie Bai ₄ , Xuenan Gu ₁ , Yufeng Zheng ₂

Affiliation

近年来，锌（Zn）及其合金作为引导骨再生（GBR）膜在治疗种植牙过程中牙槽骨体积不足和长期骨整合不稳定问题方面表现出了巨大的潜力。然而，骨再生是一个由成骨、血管生成和抗菌功能组成的复杂过程。目前，纯锌的体内成骨性能和抗菌活性还不够，因此构建一个赋予锌膜多功能的平台可能对解决这些问题至关重要。在这项研究中，制备了各种双金属镁/铜金属有机骨架（Mg/Cu-MOF）涂层并将其固定在纯锌上。结果表明，通过控制Cu ²⁺的投料比例可以调节Mg/Cu-MOF涂层的降解速率和水稳定性。随着涂层和Zn基底的降解，产生了富含Zn ²⁺ 、Mg ²⁺和Cu ²⁺的碱性微环境。它显着改善提取物中的磷酸钙沉积、成骨细胞的分化和内皮细胞的血管化。其中，Mg/Cu1表现出最好的综合性能。 Mg/Cu1在体外和体内均表现出优异的抗菌活性，与裸样品相比，其对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌的抑菌活性显着增强。双金属Mg/Cu-MOF涂层可以适当协调锌膜的多功能，并可能成为促进其骨再生的有前景的平台，这可以为锌基材料在口腔临床试验中用作屏障膜铺平道路。

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Fabrication of a Nanoscale Magnesium/Copper Metal–Organic Framework on Zn-Based Guided Bone Generation Membranes for Enhancing Osteogenesis, Angiogenesis, and Bacteriostasis Properties

Recently, zinc (Zn) and its alloys have demonstrated great potential as guided bone regeneration (GBR) membranes to treat the problems of insufficient alveolar bone volume and long-term osseointegration instability during dental implantology. However, bone regeneration is a complex process consisting of osteogenesis, angiogenesis, and antibacterial function. For now, the in vivo osteogenic performance and antibacterial activity of pure Zn are inadequate, and thus fabricating a platform to endow Zn membranes with multifunctions may be essential to address these issues. In this study, various bimetallic magnesium/copper metal–organic framework (Mg/Cu-MOF) coatings were fabricated and immobilized on pure Zn. The results indicated that the degradation rate and water stability of Mg/Cu-MOF coatings could be regulated by controlling the feeding ratio of Cu²⁺. As the coating and Zn substrate degraded, an alkaline microenvironment enriched with Zn²⁺, Mg²⁺, and Cu²⁺ was generated. It significantly improved calcium phosphate deposition, differentiation of osteoblasts, and vascularization of endothelial cells in the extracts. Among them, Mg/Cu1 showed the best comprehensive performance. The superior antibacterial activity of Mg/Cu1 was demonstrated in vitro and in vivo, which indicated significantly enhanced bacteriostatic activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli as compared to that of the bare sample. Bimetallic Mg/Cu-MOF coating could properly coordinate the multifunction on a Zn membrane and could be a promising platform for promoting its bone regeneration, which could pave the way for Zn-based materials to be used as barrier membranes in oral clinical trials.

更新日期：2024-01-24

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