The construction of axially chiral alkene frameworks is currently one of hottest topics in the field of organic synthetic chemistry. Compared to traditional axially chiral molecules, such as biaryls, heterobiaryls, and anilides, the synthesis of axially chiral alkenes is far more challenging, especially for acyclic tetrasubstituted alkene analogues. In this review, we summarized the development of strategies for the synthesis of tetrasubstituted axially chiral alkene analogues, including asymmetric difunctionalization, C–H functionalization, cross-coupling, (dynamic) kinetic resolution, and asymmetric allylic substitution-isomerization.

1 Introduction

2 Synthesis of Cyclic Tetrasubstituted Axially Chiral Alkenes

3 Synthesis of Acyclic Tetrasubstituted Axially Chiral Alkenes

4 Summary and Outlook

轴向手性烯烃骨架的构建是目前有机合成化学领域最热门的课题之一。与传统的轴向手性分子（例如联芳基、杂联芳基和苯胺）相比，轴向手性烯烃的合成更具挑战性，特别是对于无环四取代烯烃类似物。在这篇综述中，我们总结了四取代轴向手性烯烃类似物的合成策略的发展，包括不对称双官能化、C-H官能化、交叉偶联、（动态）动力学拆分和不对称烯丙基取代异构化。

1 简介

2 环状四取代轴向手性烯烃的合成

3 无环四取代轴向手性烯烃的合成

4 总结与展望