<br>中缝背核神经元的强直去甲肾上腺素能输入介导雄性小鼠的食物摄入,Behavioural Brain Research

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中缝背核神经元的强直去甲肾上腺素能输入介导雄性小鼠的食物摄入
Behavioural Brain Research ( IF 2.6 ) Pub Date : 2024-01-23 , DOI: 10.1016/j.bbr.2024.114872
Rafael Appel Flores ₁ , Raoni C Dos-Santos ₂ , Isabelle Rodrigues-Santos ₁ , Aline Alves de Jesus ₁ , José Antunes-Rodrigues ₁ , Lucila L K Elias ₁

Affiliation

中缝背核（DRN）对于控制食物摄入至关重要。 DRN 的传出预测延伸到涉及食物摄入控制的几个前脑区域。然而，DRN 中释放的与控制食物摄入相关的神经递质尚不清楚。我们之前已经证明，α1 对 DRN 神经元的强直作用有助于喂食大鼠的饱腹感。在这项研究中，我们研究了 DRN 中的去甲肾上腺素 (NE) 信号在饱腹感反应中的参与。 DRN 内给予 NE 会导致饱腹小鼠 2 小时食物摄入量增加，这一效应被之前给予育亨宾（一种 α2 拮抗剂）所阻断。同样，DRN 内给予可乐定（一种 α2 激动剂）可增加饱腹小鼠的食物摄入量。该结果表明，在饱足的小鼠中，外源性NE作用于α2受体以增加食物摄入量。此外，给予去氧肾上腺素（一种α1激动剂）会减少禁食小鼠的食物摄入量，而哌唑嗪（一种α1拮抗剂）会增加饱腹小鼠的食物摄入量。综上所述，这些结果表明，在饱腹状态下，对 DRN 神经元的强直 α1 肾上腺素能作用抑制食物摄入，而给予 DRN 的外源 NE 作用于 α2 肾上腺素能受体以增加食物摄入。这些数据强化了 DRN 复杂的神经元功能及其对进食的影响。

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Tonic noradrenergic input to neurons in the dorsal raphe nucleus mediates food intake in male mice

The dorsal raphe nucleus (DRN) is essential for the control of food intake. Efferent projections from the DRN extend to several forebrain regions that are involved in the control of food intake. However, the neurotransmitters released in the DRN related to the control of food intake are not known. We have previously demonstrated that a tonic α1 action on DRN neurons contributes to satiety in the fed rats. In this study we investigated the participation of norepinephrine (NE) signaling in the DRN in the satiety response. Intra-DRN administration of NE causes an increase in the 2-hour food intake of sated mice, an effect that was blocked by previous administration of yohimbine, an α2 antagonist. Similarly, Intra-DRN administration of clonidine, an α2 agonist, increases food intake in sated mice. This result indicates that in the satiated mice exogenous NE acts on α2 receptors to increase food intake. Furthermore, administration of phenylephrine, an α1 agonist, decreases food intake in fasted mice and prazosin, an α1 antagonist, increases food intake in the sated mice. Taken together these results indicate that, in a satiated condition, a tonic α1 adrenergic action on the DRN neurons inhibits food intake and that exogenous NE administered to the DRN acts on α2 adrenergic receptors to increase food intake. These data reinforce the intricate neuronal functioning of the DRN and its effects on feeding.

更新日期：2024-01-23

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