<br>MOF-聚合物复合材料具有均匀分布的金纳米颗粒，用于高半胱氨酸的视觉监测,Analyst

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MOF-聚合物复合材料具有均匀分布的金纳米颗粒，用于高半胱氨酸的视觉监测
Analyst ( IF 3.6 ) Pub Date : 2024-01-24 , DOI: 10.1039/d3an01934a
Yutong Liu _{1,

2} , Cheng Cheng _{1,

3} , Zhenwen Zhao _{1,

4} , Wei Liu ₂ , Li Qi _{1,

4}

Affiliation

金纳米粒子（AuNPs）在金属有机骨架（MOF）表面的分布对于MOF-AuNP复合材料的催化性能起着至关重要的作用。本研究描述了UiO-66-NH ₂ (U)表面上AuNPs的物理吸附(PH@AuNPs-on-U)和化学修饰如何影响复合材料的催化效率。将2-乙烯基-4,4-二甲基-2-恶唑啉-5-酮（VD）与聚（ N -2-羟丙基甲基丙烯酰胺）（PH）用U（UVD-PH）连接后，得到UVD-PH@AuNPs复合材料以 PH 作为封端剂和还原剂构建。该复合材料在用H ₂ O ₂氧化3,3'5,5'-四甲基联苯胺(TMB)时表现出比PH@AuNPs-on-U更高的过氧化物酶(POD)样活性。该方法表明，所提出的复合纳米酶可以显着增强其催化活性，并且 PH@AuNPs 在 UVD 表面上具有高度均匀的分布。开发了一种用于视觉检测同型半胱氨酸 (Hcy) 的纳米酶测定法，在 3.34 μM 至 30.0 μM 范围内表现出良好的线性关系 ( R ² = 0.998)，检测限为 0.3 μM。此外，UVD-PH@AuNPs-TMB-H ₂ O ₂系统成功监测大鼠腹腔注射后的血清Hcy。这项研究为开发具有高度均匀表面分布的聚合物@AuNPs的MOF-AuNPs铺平了一条新途径，以提高其催化活性并检测真实生物样品中的药物。

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MOF–polymer composites with well-distributed gold nanoparticles for visual monitoring of homocysteine

The distribution of gold nanoparticles (AuNPs) on the surface of a metal–organic framework (MOF) plays a crucial role in the catalytic performance of MOF-AuNP composites. This study describes how the physical adsorption (PH@AuNPs-on-U) and chemical modification of AuNPs on the surface of UiO-66-NH₂ (U) affect the composites’ catalytic efficiency. After 2-vinyl-4,4-dimethyl-2-oxazolin-5-one (VD) linked to poly(N-2-hydroxypropyl methacrylamide) (PH) with U (UVD-PH), UVD-PH@AuNPs composites were constructed with PH as the capping and reducing reagent. The composites exhibited higher peroxidase (POD)-like activity than PH@AuNPs-on-U for oxidising 3,3′5,5′-tetramethylbenzidine (TMB) with H₂O₂. The approach demonstrated that the proposed composite-based nanozymes could significantly enhance their catalytic activity and had a highly uniform distribution of PH@AuNPs on the surface of UVD. An assay with the nanozymes for visual detection of homocysteine (Hcy) was developed, displaying a good linear relationship (R² = 0.998) ranging from 3.34 μM to 30.0 μM and a detection of limit of 0.3 μM. Additionally, the UVD-PH@AuNPs-TMB-H₂O₂ system successfully monitored serum Hcy after intraperitoneal injection in rats. This study paves a new way for developing MOF-AuNPs with highly uniform surface distribution of polymer@AuNPs to boost its catalytic activity and to detect drugs in real bio-samples.

更新日期：2024-01-24

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