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Unique Reaction-Based Polynorbornene Sensing Probes for Ultrasensitive Detection of Hydrazine in Both Environmental and Biological Systems
Biomacromolecules ( IF 5.5 ) Pub Date : 2024-01-23 , DOI: 10.1021/acs.biomac.3c01079 Narayan Das 1 , Tapendu Samanta 1 , Sangita Rajwar 1 , Raja Shunmugam 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2024-01-23 , DOI: 10.1021/acs.biomac.3c01079 Narayan Das 1 , Tapendu Samanta 1 , Sangita Rajwar 1 , Raja Shunmugam 1
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Hydrazine-mediated formation of 1,4-phthalazinedione analogues from phthalimide-like components has been utilized to formulate fluorescent probe NorTh. A turn-on fluorescent process has been evaluated to detect hydrazine in a highly selective manner by a small molecular probe NorTh and its homopolymer Poly-NorTh. Both these probes have been evaluated as excellent candidates for nanomolar level detection of hydrazine with a time frame of <15 min, which is rapid in terms of real application. Due to the reaction-based detection process, we have achieved high selectivity for our probes toward the identification of hydrazine in the presence of metal ions, anions, amino acids, and various amines. Limit of detection values are 16 and 35 nM for NorTh and Poly-NorTh, respectively, which are well below the permissible limit given by WHO and EPA. Poly-NorTh has been utilized to detect hydrazine in environmental water samples, soil samples, and biological samples to establish the applicability of our probes in real-field scenarios. We introduce an easy-to-synthesize, cheap, and small molecular probe and its polymer for ultrafast, highly selective, and sensitive detection of hydrazine in all possible mediums to counter the hydrazine toxicity through fluorescence turn-on signal output.
中文翻译：
独特的基于反应的聚降冰片烯传感探针，用于对环境和生物系统中的肼进行超灵敏检测
肼介导的邻苯二甲酰亚胺样组分形成 1,4-邻苯二肚二酮类似物已被用于配制荧光探针 NorTh。已经评估了一种开启荧光过程，以通过小分子探针 NorTh 及其均聚物 Poly-NorTh 以高度选择性的方式检测肼。这两种探针都被评估为纳摩尔级肼检测的优秀候选者，时间范围为 <15 min，在实际应用方面是快速的。由于采用基于反应的检测过程，我们的探针在金属离子、阴离子、氨基酸和各种胺存在下对肼的鉴定实现了高选择性。NorTh 和 Poly-NorTh 的检测限值分别为 16 和 35 nM，远低于 WHO 和 EPA 给出的允许限值。Poly-NorTh 已被用于检测环境水样、土壤样和生物样中的肼，以确定我们的探针在实际场景中的适用性。我们推出了一种易于合成、价格低廉且体积小的分子探针及其聚合物，用于对所有可能的介质中的肼进行超快速、高选择性和灵敏的检测，以通过荧光开启信号输出来抵消肼的毒性。
更新日期：2024-01-23
中文翻译：
独特的基于反应的聚降冰片烯传感探针，用于对环境和生物系统中的肼进行超灵敏检测
肼介导的邻苯二甲酰亚胺样组分形成 1,4-邻苯二肚二酮类似物已被用于配制荧光探针 NorTh。已经评估了一种开启荧光过程，以通过小分子探针 NorTh 及其均聚物 Poly-NorTh 以高度选择性的方式检测肼。这两种探针都被评估为纳摩尔级肼检测的优秀候选者，时间范围为 <15 min，在实际应用方面是快速的。由于采用基于反应的检测过程，我们的探针在金属离子、阴离子、氨基酸和各种胺存在下对肼的鉴定实现了高选择性。NorTh 和 Poly-NorTh 的检测限值分别为 16 和 35 nM，远低于 WHO 和 EPA 给出的允许限值。Poly-NorTh 已被用于检测环境水样、土壤样和生物样中的肼，以确定我们的探针在实际场景中的适用性。我们推出了一种易于合成、价格低廉且体积小的分子探针及其聚合物，用于对所有可能的介质中的肼进行超快速、高选择性和灵敏的检测，以通过荧光开启信号输出来抵消肼的毒性。
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