The paper presents research on identifying a biomechanical parameter from a theoretical model of changes during osteoarthritis. In vitro experiments were carried out on quasi-3D chondrocyte cultures seeded on corn-starch hydrogel materials and subjected to mechanical stress on a designed and constructed stand. The results were adapted to a mathematical model and calculated on a simplified two-dimensional specimen. Numerical simulations have been performed to illustrate the growth of bone spurs. The observed changes of variables which determine osteophytes are qualitative and more correlated to the real-life observations.

中文翻译：

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骨赘发育的数学模型首次尝试确定生物力学参数

本文介绍了从骨关节炎变化的理论模型中识别生物力学参数的研究。对接种在玉米淀粉水凝胶材料上的准 3D 软骨细胞培养物进行体外实验，并在设计和建造的支架上承受机械应力。结果适用于数学模型并在简化的二维样本上进行计算。已经进行了数值模拟来说明骨刺的生长。观察到的决定骨赘的变量的变化是定性的，并且与现实生活中的观察结果更相关。