Discovery of 1H-pyrazolo[3,4-b]pyrazine derivatives as selective allosteric inhibitor of protein tyrosine phosphatase SHP2 for the treatment of KRASG12C-mutant non-small cell lung cancer,Journal of Biomolecular Structure and Dynamics

当前位置： X-MOL 学术 › J. Biomol. Struct. Dyn. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Discovery of 1H-pyrazolo[3,4-b]pyrazine derivatives as selective allosteric inhibitor of protein tyrosine phosphatase SHP2 for the treatment of KRASG12C-mutant non-small cell lung cancer
Journal of Biomolecular Structure and Dynamics ( IF 2.7 ) Pub Date : 2024-01-23 , DOI: 10.1080/07391102.2024.2308771
Wen-Qiang Xu ₁ , Shi-Zhou Qi ₁ , Ji-Feng Zhao ₂ , Li-Peng Li ₃ , Chuan-Hua Ding ₂ , Wen-Shan Liu _{2,

4}

Affiliation

The high expression or mutation of SHP2 can induce cancer, so targeting SHP2 has become a new strategy for cancer treatment. In this study, we used the previously reported SHP2 allosteric inhibitor...

中文翻译：