Synthesis, characterization of novel N-(4-cyano-1,3-oxazol-5-yl)sulfonamide derivatives and in vitro screening their activity against NCI-60 cancer cell lines,ChemMedChem

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Synthesis, characterization of novel N-(4-cyano-1,3-oxazol-5-yl)sulfonamide derivatives and in vitro screening their activity against NCI-60 cancer cell lines
ChemMedChem ( IF 3.6 ) Pub Date : 2024-01-19 , DOI: 10.1002/cmdc.202300527
Oleksandr Severin ₁ , Stepan Pilyo ₁ , Maryna Kachaeva ₁ , Victor Zhirnov ₁ , Diana Hodyna ₂ , Oksana Bahrieieva ₁ , Volodymyr Brovarets ₁

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A series of 14 new sulfonylamides – 1,3-oxazole derivatives are synthesized and investigated against NCI 60 cancer cell lines. COMPARE analysis is conducted for compounds 2 and 10 and considering moderate correlation with the L-cysteine analog (r=0.57) and maytasine (r=0.53). In view of the positive anticancer results, N-(4-cyano-1,3-oxazol-5-yl)-sulfonamides may be promising for further functionalization to obtain more active compounds.

中文翻译：

新型N-(4-氰基-1,3-恶唑-5-基)磺酰胺衍生物的合成、表征及其针对NCI-60癌细胞系的体外活性筛选

合成了一系列 14 种新型磺酰胺 - 1,3-恶唑衍生物，并针对 NCI 60 癌细胞系进行了研究。对化合物 2 和 10 进行比较分析，并考虑与 L-半胱氨酸类似物 (r=0.57) 和美他辛 (r=0.53) 的中度相关性。鉴于积极的抗癌效果，N-(4-氰基-1,3-恶唑-5-基)-磺酰胺有望进一步功能化以获得更具活性的化合物。

更新日期：2024-01-19

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