Effect of trimethylene carbonate segments on the structure and properties of poly(L-lactide-glycolide-trimethylene carbonate) terpolymers for biodegradable vascular stents,Journal of Applied Polymer Science

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Effect of trimethylene carbonate segments on the structure and properties of poly(L-lactide-glycolide-trimethylene carbonate) terpolymers for biodegradable vascular stents
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2024-01-20 , DOI: 10.1002/app.55208
Qi Xia ₁ , Dongyang Liu ₁ , Qiuming Jin ₁ , Shinuo Zhang ₁ , Wenjie Yu ₁ , Zhongyong Fan ₁ , Qing Liu ₂ , Lu Cao _{3,

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Affiliation

The total biodegradable vascular stent made of poly(L-lactide-glycolide-trimethylene carbonate) terpolymers with excellent performances has the potential to be used in a new generation of medical implant devices. In this work, the properties and structure of terpolymers were investigated, which were found to be controlled by the composition of the copolymer chain. The amorphous trimethylene carbonate segments not only disturbed the sequence regularity of the L-lactide segment, but also reduced the crystallization ability of the material. Furthermore, it is the flexible segments in the terpolymer chains that improve the plastic flow capacity, increase the flexibility of chains as well as reduce the apparent activation energy of thermal degradation of materials. Such a chain structured terpolymer exhibited good extrudability and buildability in 3D printing and formed a vascular stent with a cohesion entanglement characteristic microstructure during the process. The crush resistance with radially applied load and crush resistance with parallel plates of stent were 2561.4 mm Hg and 0.24 N/mm, respectively.

中文翻译：

三亚甲基碳酸酯链段对生物可降解血管支架用聚(L-丙交酯-乙交酯-三亚甲基碳酸酯)三元共聚物结构和性能的影响

由聚(L-丙交酯-乙交酯-三亚甲基碳酸酯)三元共聚物制成的全生物可降解血管支架具有优异的性能，具有用于新一代医疗植入器械的潜力。在这项工作中，研究了三元共聚物的性能和结构，发现这些性能和结构受共聚物链的组成控制。无定形三亚甲基碳酸酯链段不仅扰乱了L-丙交酯链段的序列规律性，而且降低了材料的结晶能力。此外，三元共聚物链中的柔性链段提高了塑性流动能力，增加了链的柔韧性并降低了材料热降解的表观活化能。这种链状结构的三元共聚物在3D打印中表现出良好的可挤出性和可构建性，并在此过程中形成具有内聚缠结特征微结构的血管支架。支架的径向施加载荷的抗压强度和平行板的抗压强度分别为2561.4mm Hg和0.24N/mm。

更新日期：2024-01-20

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