<br>负载 bFGF 的聚（桦木酸）纳米粒子可改善脊髓损伤后的功能恢复,Advanced Healthcare Materials

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负载 bFGF 的聚（桦木酸）纳米粒子可改善脊髓损伤后的功能恢复
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2024-01-20 , DOI: 10.1002/adhm.202303462
Xianghang Chen _{1,

2,

3} , Beini Wang ₄ , Yongxiu Zhou ₄ , Xuejuan Wu ₄ , Anyu Du ₄ , Abdullah Al Mamun _{3,

5} , Yitie Xu ₄ , Shuangshuang Wang ₁ , Chang Jiang ₁ , Ling Xie ₃ , Kailiang Zhou ₆ , Siwang Hu ₁ , Jian Xiao _{1,

4,

6}

Affiliation

氧化应激（OS）是继发性脊髓损伤（SCI）的关键分子事件之一。碱性成纤维细胞生长因子（bFGF）是一种具有抗氧化作用的多能细胞生长因子。然而，bFGF体内半衰期短，限制了其治疗应用。具有优异生物相容性的可生物降解聚合物最近已在SCI中得到应用。缺点是聚合物不能提供显着的治疗效果。桦木酸（BA）是一种天然抗炎化合物，已被聚合成聚（桦木酸）（PBA），作为bFGF的药物载体。本研究探讨了负载 bFGF 的 PBA 纳米颗粒 (NPs) (PBA-bFGF NPs) 在 SCI 中的治疗效果和潜在分子机制。结果表明，PBA-bFGF NPs 在体内和体外均具有显着的生物相容性。结果还表明，局部递送 PBA-bFGF NP 可增强运动功能恢复、抑制 OS、减轻神经炎症并减轻 SCI 后的神经元凋亡。此外，结果表明，局部递送 PBA-bFGF NP 可在 SCI 后激活核因子红细胞 2 相关因子 2 (Nrf-2) 信号通路。总之，结果表明 PBA-bFGF NP 的局部递送在 SCI 的治疗和管理中具有潜在的治疗优势。

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Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury

Oxidative stress (OS) is one of the crucial molecular events of secondary spinal cord injury (SCI). Basic fibroblast growth factor (bFGF) is a multipotent cell growth factor with an anti-oxidant effect. However, bFGF has a short half-life in vivo, which limits its therapeutic application. Biodegradable polymers with excellent biocompatibility have been recently applied in SCI. The negative aspect is that polymers cannot provide a significant therapeutic effect. Betulinic acid (BA), a natural anti-inflammatory compound, has been polymerized into poly (betulinic acid) (PBA) to serve as a drug carrier for bFGF. This study explores the therapeutic effects and underlying molecular mechanisms of PBA nanoparticles (NPs) loaded with bFGF (PBA-bFGF NPs) in SCI. Results show that PBA-bFGF NPs produce remarkable biocompatibility in vivo and in vitro. The results also demonstrate that local delivery of PBA-bFGF NPs enhances motor function recovery, inhibits OS, mitigates neuroinflammation, and alleviates neuronal apoptosis following SCI. Furthermore, the results indicate that local delivery of PBA-bFGF NPs activates the nuclear factor erythroid 2-related factor 2 (Nrf-2) signaling pathway following SCI. In summary, results suggest that local delivery of PBA-bFGF NPs delivers potential therapeutic advantages in the treatment and management of SCI.

更新日期：2024-01-20

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