Material Analysis of Explanted Calcified Silicone Intraocular Lenses in Association with Asteroid Hyalosis,Ophthalmology and Therapy

当前位置： X-MOL 学术 › Ophthalmol. Ther. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Material Analysis of Explanted Calcified Silicone Intraocular Lenses in Association with Asteroid Hyalosis
Ophthalmology and Therapy ( IF 2.6 ) Pub Date : 2024-01-20 , DOI: 10.1007/s40123-023-00872-0
Lizaveta Chychko ₁ , Ramin Khoramnia ₁ , Hyeck-Soo Son ₁ , Sonja K Schickhardt ₁ , Ingo Lieberwirth ₂ , Gerd U Auffarth _{1,

3} , Timur M Yildirim ₁

Affiliation

Introduction

The aim of this study was to analyze posterior surface opacification in explanted silicone intraocular lenses (IOLs) with clinicopathologic correlation to asteroid hyalosis.

Methods

In a laboratory setup, 12 explanted silicone IOLs underwent laboratory analyses, including light microscopy, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy for elemental composition (EDX). Relevant clinical data were obtained for each case, including gender, age at IOL implantation, dates of implantation and explantation, as well as history of neodymium-dopped yttrium aluminum garnet (Nd:YAG) laser treatments or other opacification removal attempts. High-resolution optical coherence tomography (OCT) images were obtained in vitro with an anterior segment OCT device (Anterion, Heidelberg Engineering, Heidelberg, Germany).

Results

Calcification located at the posterior optic surface of each lens was identified through SEM and EDX analyses, revealing deposits composed of hydroxyapatite. In all cases, IOL polishing using Nd:YAG laser had been attempted prior to IOL exchange. The clinical functional data showed that this type of IOL opacity led to increase in straylight and subjective symptoms of glare.

Conclusions

Silicone IOLs can develop posterior surface calcification in eyes with asteroid hyalosis. There are mechanical techniques of cleaning the IOL surface but in many cases, IOL explantation is the only sustainable way to reduce the patients’ straylight levels and glare symptoms. Due to the risk of posterior surface calcification, silicone IOL implantation should be avoided in eyes with asteroid hyalosis.

中文翻译：

与小行星玻璃变性相关的移植钙化硅胶人工晶状体的材料分析

介绍

本研究的目的是分析移植硅胶人工晶状体（IOL）后表面混浊与小行星玻璃变性的临床病理相关性。

方法

在实验室设置中，对 12 个移植的硅胶 IOL 进行了实验室分析，包括光学显微镜、扫描电子显微镜 (SEM) 和元素成分能量色散 X 射线光谱 (EDX)。获得每个病例的相关临床数据，包括性别、人工晶状体植入时的年龄、植入和取出的日期，以及掺钕钇铝石榴石（Nd:YAG）激光治疗或其他混浊去除尝试的历史。使用眼前段 OCT 设备（Anterion，海德堡工程公司，海德堡，德国）在体外获得高分辨率光学相干断层扫描 (OCT) 图像。