Extracellular Vesicles for Drug Delivery and Theranostics In Vivo,JACS Au

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Extracellular Vesicles for Drug Delivery and Theranostics In Vivo
JACS Au ( IF 8.5 ) Pub Date : 2024-01-18 , DOI: 10.1021/jacsau.3c00611
Tatini Rakshit ₁ , Suchetan Pal ₂

Affiliation

Extracellular vesicles (EVs) are lipid bilayer-enclosed nanopouches generated by all cells and are abundant in various body fluids. Depending on the parent and recipient cells, EVs exchange diverse constituents including nucleic acids, proteins, carbohydrates, and metabolites. Morphologically, EVs suffer from low zeta potentials and short circulation times, but they also offer low intrinsic immunogenicity and inherent stability. Some crucial factors for the effective clinical application of EVs include controlling immune system clearance, achieving the large-scale production of EVs with efficient quality control, and determining the dominant mechanism of the in vivo action of EVs. In this Perspective, we shed light on how these intriguing nano-objects are utilized in cellular imaging and drug delivery for disease therapeutics. We also discuss potential strategies for overcoming the associated limitations.

中文翻译：

用于体内药物输送和治疗诊断的细胞外囊泡

细胞外囊泡（EV）是所有细胞产生的脂质双层封闭的纳米囊，在各种体液中含量丰富。根据亲本细胞和受体细胞的不同，EV 交换不同的成分，包括核酸、蛋白质、碳水化合物和代谢物。从形态上讲，EV 具有低 Zeta 电位和短循环时间的问题，但它们也具有低内在免疫原性和固有稳定性。 EVs有效临床应用的一些关键因素包括控制免疫系统清除、在有效的质量控制下实现EVs的大规模生产以及确定EVs体内作用的主导机制。在这篇文章中，我们阐明了如何将这些有趣的纳米物体用于细胞成像和疾病治疗的药物输送。我们还讨论了克服相关限制的潜在策略。

更新日期：2024-01-18

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