3D printing of heart valves,Trends in Biotechnology

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3D printing of heart valves
Trends in Biotechnology ( IF 14.3 ) Pub Date : 2024-01-18 , DOI: 10.1016/j.tibtech.2023.11.001
Michael J Vernon ₁ , Petra Mela ₂ , Rodney J Dilley ₃ , Shirley Jansen ₄ , Barry J Doyle ₅ , Abdul R Ihdayhid ₆ , Elena M De-Juan-Pardo ₇

Affiliation

T3mPLATE, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre and University of Western Australia Centre for Medical Research, The University of Western Australia, Perth, WA 6009, Australia; Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre and University of Western Australia Centre for Medical Research, The University of Western Australia, Perth, WA 6009, Australia; School of Engineering, The University of Western Australia, Perth, WA 6009, Australia.
Medical Materials and Implants, Department of Mechanical Engineering, Munich Institute of Biomedical Engineering and TUM School of Engineering and Design, Technical University of Munich, Boltzmannstrasse 15, 85748 Garching, Germany.
T3mPLATE, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre and University of Western Australia Centre for Medical Research, The University of Western Australia, Perth, WA 6009, Australia.
Curtin Medical School, Curtin University, Perth, WA 6102, Australia; School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, WA 6009, Australia; Department of Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia; Heart and Vascular Research Institute, Harry Perkins Institute of Medical Research, Perth, WA 6009, Australia.
Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre and University of Western Australia Centre for Medical Research, The University of Western Australia, Perth, WA 6009, Australia; School of Engineering, The University of Western Australia, Perth, WA 6009, Australia.
T3mPLATE, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre and University of Western Australia Centre for Medical Research, The University of Western Australia, Perth, WA 6009, Australia; Curtin Medical School, Curtin University, Perth, WA 6102, Australia; Department of Cardiology, Fiona Stanley Hospital, Perth, WA 6150, Australia.
T3mPLATE, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre and University of Western Australia Centre for Medical Research, The University of Western Australia, Perth, WA 6009, Australia; School of Engineering, The University of Western Australia, Perth, WA 6009, Australia; Curtin Medical School, Curtin University, Perth, WA 6102, Australia.

3D printing technologies have the potential to revolutionize the manufacture of heart valves through the ability to create bespoke, complex constructs. In light of recent technological advances, we review the progress made towards 3D printing of heart valves, focusing on studies that have utilised these technologies beyond manufacturing patient-specific moulds. We first overview the key requirements of a heart valve to assess functionality. We then present the 3D printing technologies used to engineer heart valves. By referencing International Organisation for Standardisation (ISO) Standard 5840 (Cardiovascular implants – Cardiac valve prostheses), we provide insight into the achieved functionality of these valves. Overall, 3D printing promises to have a significant positive impact on the creation of artificial heart valves and potentially unlock full complex functionality.

中文翻译：

3D打印心脏瓣膜

3D 打印技术有潜力通过创建定制的复杂结构来彻底改变心脏瓣膜的制造。鉴于最近的技术进步，我们回顾了心脏瓣膜 3D 打印方面取得的进展，重点关注除了制造患者专用模具之外还利用这些技术的研究。我们首先概述心脏瓣膜的关键要求以评估功能。然后我们介绍用于设计心脏瓣膜的 3D 打印技术。通过参考国际标准化组织 (ISO) 标准 5840（心血管植入物 - 心脏瓣膜假体），我们深入了解这些瓣膜所实现的功能。总体而言，3D 打印有望对人造心脏瓣膜的制造产生显着的积极影响，并有可能解锁完整的复杂功能。

更新日期：2024-01-18

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