IgE to cross-reactive carbohydrate determinants (CCD) in childhood: Prevalence, risk factors, putative origins,Clinical & Experimental Allergy

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IgE to cross-reactive carbohydrate determinants (CCD) in childhood: Prevalence, risk factors, putative origins
Clinical & Experimental Allergy ( IF 6.3 ) Pub Date : 2024-01-17 , DOI: 10.1111/cea.14439
Ekaterina Potapova ₁ , Salvatore Tripodi ₂ , Valentina Panetta ₃ , Stephanie Dramburg ₁ , Roberto Bernardini ₄ , Carlo Caffarelli ₅ , Antonella Casani ₆ , Rosa Cervone ₄ , Loredana Chini ₇ , Pasquale Comberiati ₈ , Giovanna De Castro ₉ , Michele Miraglia Del Giudice ₁₀ , Iride Dello Iacono ₁₁ , Andrea Di Rienzo Businco ₂ , Marcella Gallucci ₁₂ , Arianna Giannetti ₁₂ , Viviana Moschese ₇ , Ifigenia Sfika ₂ , Elena Varin ₁₃ , Riccardo Asero ₁₄ , Annamaria Bianchi ₁₅ , Mauro Calvani ₁₅ , Tullio Frediani ₉ , Francesco Macrì ₉ , Nunzia Maiello ₁₀ , Francesco Paravati ₁₆ , Umberto Pelosi ₁₇ , Diego Peroni ₁₈ , Giuseppe Pingitore ₁₉ , Mariangela Tosca ₂₀ , Anna Maria Zicari ₉ , Giampaolo Ricci ₁₂ , , Gerald Reese ₂₁ , Linus Grabenhenrich ₂₂ , Katja Icke ₂₂ , Armin Grübl ₂₃ , Christoph Müller ₂₄ , Fred Zepp ₂₅ , Antje Schuster ₂₆ , Ulrich Wahn ₂₇ , Susanne Lau ₁ , Thomas Keil _{22,

28,

29} , Paolo Maria Matricardi ₁

Affiliation

Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Pediatric Department and Pediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy.
Consultancy & Training, Biostatistics, Rome, Italy.
Pediatric Unit, San Giuseppe Hospital, Empoli, Italy.
Department of Medicine and Surgery, Clinica Pediatrica, University of Parma, Parma, Italy.
Pediatra di Libera Scelta, Benevento, Italy.
UOSD di Immunopatologia ed Allergologia Pediatrica, Policlinico Tor Vergata, Università di Roma Tor Vergata, Rome, Italy.
Department of Clinical and Experimental Medicine, Section of Paediatrics, University of Pisa, Pisa, Italy.
Pediatric Department, La Sapienza University, Rome, Italy.
Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università della Campania Luigi Vanvitelli, Naples, Italy.
Pediatric Unit, Fatebenefratelli Hospital, Benevento, Italy.
Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Pediatric Intermediate Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Allergology Service, San Carlo Clinic, Milan, Paderno Dugnano, Italy.
Pediatric Unit, San Camillo Forlanini Hospital, Rome, Italy.
Pediatric Unit, Crotone, Italy.
Pediatric Unit, Santa Barbara Hospital, Iglesias, Italy.
Department of Life and Reproduction Sciences, Pediatric Section, University of Verona, Verona, Italy.
Pediatric Unit, Grassi Hospital, Rome, Italy.
Pulmonary Disease and Allergy Unit, G. Gaslini Hospital, Genoa, Italy.
Research and Development Division, Allergopharma Joachim Ganzer KG, Reinbek, Germany.
Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Department of Pediatrics, Technical University of Munich, Munich, Germany.
Center for Pediatrics and Adolescent Medicine, University Medical Centre and Faculty of Medicine Freiburg, Freiburg im Breisgau, Germany.
Department of Pediatrics and Adolescent Medicine, University Medicine Mainz, Mainz, Germany.
Department of Pediatrics, Heinrich-Heine-University, Düsseldorf, Germany.
Department of Pediatric Respiratory Medicine and Immunology, Former director of Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
State Institute of Health, Bavarian Health and Food Safety Authority, Erlangen, Germany.

IgE antibodies to cross-reactive carbohydrate determinants (CCD) are usually clinically irrelevant but they can be a cause of false positive outcomes of allergen-specific IgE tests in vitro. Their prevalence and levels have been so far cross-sectionally examined among adult allergic patients and much less is known about their origins and relevance in childhood.

中文翻译：

儿童期 IgE 与交叉反应碳水化合物决定因素 (CCD)：患病率、危险因素、假定起源

交叉反应性碳水化合物决定簇 (CCD) 的 IgE 抗体通常与临床无关，但它们可能是体外过敏原特异性 IgE 测试出现假阳性结果的原因。迄今为止，已在成年过敏患者中对它们的患病率和水平进行了横断面检查，但对其起源和儿童时期的相关性知之甚少。

更新日期：2024-01-17

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