<br>通过多种个人基质评估人类对传统和新型有机磷酸酯的暴露,Environmental Science & Technology

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通过多种个人基质评估人类对传统和新型有机磷酸酯的暴露
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2024-01-18 , DOI: 10.1021/acs.est.3c07282
Youhua Zhao _{1,

2} , Yujuan Fan ₁ , Jing Li ₁ , Yanyan Liu ₁ , Yinyi Lv ₁ , Leicheng Zhao ₁ , Guodong Hou _{1,

2} , Zhen An ₂ , Wenwen Cai ₁ , Xue Li ₁ , Weidong Wu ₂ , Zhiguo Cao ₁

Affiliation

本文对64名大学生的皮肤擦拭物、个人PM _2.5 、痰液和指甲（手指甲和脚趾甲）中的16种传统和13种新型有机磷酸酯（OPE）以及尿液中同步获得的7种OPE代谢物进行了分析。在皮肤擦拭物和指甲以及个人 PM _2.5和诱导痰中发现了类似的 OPE 成分。皮肤擦拭物和指甲中的高亲脂性低挥发性 OPE 浓度之间以及个人 PM _2.5和痰液中高挥发性低亲脂性 OPE 浓度之间观察到显着相关性。这些结果表明，手指甲和脚趾甲中的 OPEs 可能主要来自外部来源，而不是内部暴露，而人的指甲和痰可以作为人体暴露于 OPEs 的指标。个人 PM _2.5和痰液中 OPE 的每日暴露剂量的比较表明，挥发性化合物越多，吸入生物利用度可能越高，应考虑提高吸入暴露评估的准确性。根据综合的外部和内部暴露评估，皮肤吸收可能是比吸入更主要的途径，而皮肤擦拭可能是人类暴露于 OPE 的最佳代表性环境基质。

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Assessment of Human Exposure to Traditional and Novel Organophosphate Esters via Multiple Personal Matrices

Herein, 16 traditional and 13 novel organophosphate esters (OPEs) in skin wipes, personal PM_2.5, sputum, and nails (fingernails and toenails) and 7 OPE metabolites in urine synchronously obtained from 64 college students were analyzed. Similar compositional profiles of the OPEs were found in skin wipes and nails and in personal PM_2.5 and induced sputum. Significant correlations were observed between the concentrations of high-lipophilicity low-volatility OPEs in skin wipes and nails and between the concentrations of high-volatility low-lipophilicity OPEs in personal PM_2.5 and sputum. These results imply that OPEs in fingernails and toenails may mainly come from external sources rather than internal exposure, and human nails and sputum can be used as indicators of human exposure to OPEs. A comparison between the daily exposure doses of the OPEs in personal PM_2.5 and sputum shows that more volatile compounds may have higher inhalation bioavailability, which should be considered to improve the accuracy of inhalation exposure assessments. According to comprehensive external and internal exposure assessment, dermal absorption may be a more dominant pathway than inhalation, and skin wipes may be the best representative environmental matrix of human exposure to OPEs.

更新日期：2024-01-18

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