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Raynaud phenomenon: from GWAS to drug repurposing
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2024-01-16 , DOI: 10.1038/s41584-024-01076-x Ariane L Herrick 1 , Gisela Orozco 1
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2024-01-16 , DOI: 10.1038/s41584-024-01076-x Ariane L Herrick 1 , Gisela Orozco 1
Affiliation
The identification of novel risk variants in the largest genome-wide association study of Raynaud phenomenon to date provides insights into the pathophysiology of the condition, including the potential role for α2A-adrenoceptors, and suggests opportunities for drug repurposing.
中文翻译:
雷诺现象:从 GWAS 到药物再利用
迄今为止最大的雷诺现象全基因组关联研究中新风险变异的鉴定,提供了对该疾病病理生理学的深入了解,包括α2A-肾上腺素受体的潜在作用,并为药物重新利用提供了机会。
更新日期:2024-01-16
中文翻译:
雷诺现象:从 GWAS 到药物再利用
迄今为止最大的雷诺现象全基因组关联研究中新风险变异的鉴定,提供了对该疾病病理生理学的深入了解,包括α2A-肾上腺素受体的潜在作用,并为药物重新利用提供了机会。