用于脂溶性成骨药物的高效装载和直接跨膜递送以增强钛植入物骨整合的疏水涂层平台,Advanced Functional Materials

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用于脂溶性成骨药物的高效装载和直接跨膜递送以增强钛植入物骨整合的疏水涂层平台
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-01-18 , DOI: 10.1002/adfm.202314005
Yicheng Chen ₁ , Xiaona Ning ₂ , Xuelian Jia ₁ , He Xin ₃ , Shaolingzhuo Kong ₁ , Ben Wu ₄ , Tiexin Ding ₅ , Simin Zhu _{1,

6} , Xiaomin Ren ₇ , Xiao Zhang _{1,

6} , Zihan Lu _{1,

6} , Yufan Zhang ₁ , Wenhui Zhang ₁ , Yu Zhang _{1,

8} , Liang Kong ₁ , Guocheng Wang ₄ , Fuwei Liu ₁

Affiliation

与水溶性成骨药物相比，脂溶性成骨药物具有更高的生物利用度和药物稳定性，对于增强种植体的骨整合具有重要价值。然而，现有的载药涂层主要是为水溶性药物设计的，限制了它们装载和递送脂溶性成骨药物的有效性。本研究采用碱处理、硅烷化和油酸酰化依次对钛合金表面进行改性，旨在制备能够有效负载和递送脂溶性成骨药物的表面。结果表明，脂溶性成骨药物的亲水性和负载能力强烈依赖于酰化处理的持续时间。此外，药物释放机制涉及从涂层直接扩散到接触的细胞，从而提高生物利用度，而不是扩散到周围介质和随后的细胞摄取。使用维生素D3 (VD ₃ )作为模型药物的体外实验证实，该涂层通过高效输送VD ₃有效促进骨形成。此外，体内实验表明，负载VD _{3 的}亲脂性表面显着增强了成骨能力并改善了钛种植体的骨整合。这项研究为将脂溶性药物装载到钛种植体上提供了一种有前景的策略，并提供了直接的实验证据证明脂溶性药物在促进种植体骨整合方面的重要价值。

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Hydrophobic Coating Platforms for High-Efficiency Loading and Direct Transmembrane Delivery of Fat-Soluble Osteogenic Drug for Enhanced Osseointegration of Titanium Implants

Compared with water-soluble osteogenic drugs, fat-soluble osteogenic drugs exhibit higher bioavailability and drug stability, making them valuable for enhancing the osseointegration of implants. However, existing drug-loading coatings are primarily designed for water-soluble drugs, limiting their effectiveness in loading and delivering fat-soluble osteogenic drugs. This study employed alkali treatment, silanization, and oleic acid acylation to sequentially modify the surface of Ti alloy, aiming to fabricate surfaces capable of efficiently loading and delivering fat-soluble osteogenic drugs. Results show that the hydrophilicity and loading capacity of fat-soluble osteogenic drugs strongly depended on the duration of the acylation treatment. Furthermore, the drug release mechanism involved direct diffusion from the coating to the cells in contact, resulting in improved bioavailability, as opposed to diffusion into the surrounding medium and subsequent cellular uptake. In vitro experiments using vitamine D3 (VD₃) as a model drug confirmed that the coating effectively promoted bone formation through the highly efficient delivery of VD₃. Furthermore, in vivo experiments demonstrated that the VD₃-loaded lipophilic surface significantly enhanced osteogenic capability and improved the osseointegration of titanium implants. This study provides a promising strategy for loading fat-soluble drugs onto Ti implants and direct experimental evidence demonstrating the significant value of fat-soluble drugs in promoting implant osseointegration.

更新日期：2024-01-18

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