Releasing the TLE3 break to put TCM cells on a fast track,Nature Immunology

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Releasing the TLE3 break to put TCM cells on a fast track
Nature Immunology ( IF 27.7 ) Pub Date : 2024-01-18 , DOI: 10.1038/s41590-023-01732-6
Jian Shen ₁ , Siying Lin _{1,

2} , Weiguo Cui ₁

Affiliation

The transcription cofactor TLE3 interacts with RUNX3 and TCF1 to repress the transcription and chromatin accessibility of CD8+ TCM cell signature genes, while simultaneously acting as a coactivator for TBET to facilitate the expression of CD8+ TEM cell signature genes. As such, TLE3 serves as a gatekeeper of CD8+ TCM cell formation.

中文翻译：

释放TLE3突破让中医细胞走上快车道

转录辅因子 TLE3 与 RUNX3 和 TCF1 相互作用，抑制 CD8+ TCM 细胞特征基因的转录和染色质可及性，同时充当 TBET 的共激活剂，促进 CD8+ TEM 细胞特征基因的表达。因此，TLE3 充当 CD8+ TCM 细胞形成的看门人。

更新日期：2024-01-18

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