Recently, photothermal nanomaterials has attracted enormous interests owing to their enhanced therapeutic effects and less adverse effects in the treatment of infectious diseases. Herein, this work presents a photothermally responsive antimicrobial, bioadhesive hydrogel through three dimensions (3D) printing technology for treatment the wound infection. The hydrogel is based on a visible-light-activated naturally derived polymer (GelMA), GelMA grafted with dopamine (GelMA-DA) and the polydopamine coated reduced graphene oxide (rGO@PDA), which can provide the multifunctional such as photothermal antibacterial, antioxidant, conductivity, adhesion and hemostasis performance to accelerate wound healing. The developed hydrogel shown the excellent adhesion capability to adhere the in vitro physiological tissues and glass surface. Moreover, the fabricated hydrogel also exhibited excellent cytocompatibility to L929 cells which is a vital biofunction for efficiently promoting cell proliferation and migration in vitro. The hydrogel also showed remarkable photothermally responsive antimicrobial capability against two strains (99.3 % antibacterial ratio for E. coli and 98.6 % antibacterial ratio for S. aureus). Furthermore, it could support the wound repair and regeneration of S. aureus infected full-thickness wound defects in rats. Overall, the 3D printed hydrogel could be used as a photothermal platform for the development of more effective therapies against the infected wound.

近年来，光热纳米材料因其在感染性疾病治疗中增强的治疗效果和较少的副作用而引起了人们的极大兴趣。在此，这项工作通过三维（3D）打印技术提出了一种光热响应抗菌、生物粘附水凝胶来治疗伤口感染。该水凝胶基于可见光激活的天然衍生聚合物（GelMA）、接枝多巴胺的GelMA（GelMA-DA）和聚多巴胺涂覆的还原氧化石墨烯（rGO@PDA），可提供光热抗菌、抗氧化、导电、粘附和止血性能，加速伤口愈合。所开发的水凝胶显示出优异的粘附能力，可粘附体外生理组织和玻璃表面。此外，制备的水凝胶还表现出与L929细胞优异的细胞相容性，这对于有效促进体外细胞增殖和迁移具有重要的生物功能。该水凝胶还对两种菌株表现出显着的光热响应抗菌能力（对大肠杆菌的抗菌率为 99.3%，对金黄色葡萄球菌的抗菌率为 98.6%）。此外，它可以支持大鼠金黄色葡萄球菌感染的全层伤口缺损的伤口修复和再生。总体而言，3D打印水凝胶可以用作光热平台，用于开发针对感染伤口的更有效疗法。