<br>金属有机框架（MOF）在癌症治疗中的生物医学应用：刺激响应和仿生纳米复合材料在靶向递送、光疗和诊断中的应用,International Journal of Biological Macromolecules

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金属有机框架（MOF）在癌症治疗中的生物医学应用：刺激响应和仿生纳米复合材料在靶向递送、光疗和诊断中的应用
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2024-01-17 , DOI: 10.1016/j.ijbiomac.2024.129391
Beixu Li ₁ , Milad Ashrafizadeh ₂ , Taiwei Jiao ₃

Affiliation

纳米技术是一个跨学科领域，已成为癌症治疗的热门话题。金属有机框架（MOF）是由有机连接体和金属阳离子组成的多孔材料和杂化复合材料。尽管MOFs在其他领域有着广泛的应用，但最近的研究揭示了MOFs用于癌症治疗的潜力。高表面积和孔隙率、显着的载药量和封装效率是在药物输送中使用 MOF 的好处之一。 MOF 可以选择性地靶向肿瘤细胞来递送基因/药物，这可以通过配体的功能化来实现。光敏剂和光响应纳米结构（包括碳点和金纳米颗粒）可以加载到 MOF 中/上，以引起光疗介导的肿瘤消融。 MOF 平台在提供肿瘤细胞免疫治疗时可以加速免疫原性细胞死亡诱导和细胞毒性 CD 和 CD T 细胞浸润的增加。对 pH、氧化还原、酶和离子有响应的刺激响应 MOF 平台可以加速肿瘤部位治疗药物的释放。此外，MOF纳米复合材料可以修饰配体和绿色聚合物，以提高其癌症治疗的选择性和生物相容性。应用MOFs检测癌症相关生物标志物可以参与患者的早期诊断。

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Biomedical application of metal-organic frameworks (MOFs) in cancer therapy: Stimuli-responsive and biomimetic nanocomposites in targeted delivery, phototherapy and diagnosis

The nanotechnology is an interdisciplinary field that has become a hot topic in cancer therapy. Metal-organic frameworks (MOFs) are porous materials and hybrid composites consisted of organic linkers and metal cations. Despite the wide application of MOFs in other fields, the potential of MOFs for purpose of cancer therapy has been revealed by the recent studies. High surface area and porosity, significant drug loading and encapsulation efficiency are among the benefits of using MOFs in drug delivery. MOFs can deliver genes/drugs with selective targeting of tumor cells that can be achieved through functionalization with ligands. The photosensitizers and photo-responsive nanostructures including carbon dots and gold nanoparticles can be loaded in/on MOFs to cause phototherapy-mediated tumor ablation. The immunogenic cell death induction and increased infiltration of cytotoxic CD and CD T cells can be accelerated by MOF platforms in providing immunotherapy of tumor cells. The stimuli-responsive MOF platforms responsive to pH, redox, enzyme and ion can accelerate release of therapeutics in tumor site. Moreover, MOF nanocomposites can be modified ligands and green polymers to improve their selectivity and biocompatibility for cancer therapy. The application of MOFs for the detection of cancer-related biomarkers can participate in the early diagnosis of patients.

更新日期：2024-01-17

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