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Chlorfenapyr Crystal Polymorphism and Insecticidal Activity
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2024-01-17 , DOI: 10.1021/acs.cgd.3c01257 Reese Aronin 1 , Petr Brázda 2 , Leilani N Smith 1 , Carolyn Jin Zhang 1 , Jason B Benedict 3 , Zoe Y Marr 3 , Boris Rybtchinski 4 , Haim Weissman 4 , Alexander G Shtukenberg 1 , Bart Kahr 1
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2024-01-17 , DOI: 10.1021/acs.cgd.3c01257 Reese Aronin 1 , Petr Brázda 2 , Leilani N Smith 1 , Carolyn Jin Zhang 1 , Jason B Benedict 3 , Zoe Y Marr 3 , Boris Rybtchinski 4 , Haim Weissman 4 , Alexander G Shtukenberg 1 , Bart Kahr 1
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Four crystalline polymorphs of the proinsecticide chlorfenapyr [4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluoromethyl-1H-pyrrole-3-carbonitrile] have been identified and characterized by polarized light optical microscopy, differential scanning calorimetry, Raman spectroscopy, X-ray diffraction, and electron diffraction. Three of the four structures were considered polytypic. Chlorfenapyr polymorphs show similar lethality against fruit flies (Drosophila melanogaster) and mosquitoes (Anopheles quadrimaculatus) with the least stable polymorph showing slightly higher lethality. Similar activities may be expected to be consistent with structural similarities. Knockdown kinetics, however, depend on an internal metabolic activating step, which further complicates polymorph-dependent bioavailability.
中文翻译：
虫螨腈晶体多态性与杀虫活性
杀虫剂前体虫螨吡的四种结晶多晶型物 [4-溴-2-(4-氯苯基)-1-乙氧基甲基-5-三氟甲基-1 H-吡咯-3-甲腈]已通过偏光光学显微镜、差示扫描技术进行鉴定和表征量热法、拉曼光谱、X 射线衍射和电子衍射。四种结构中的三种被认为是多型的。氯芬那吡多晶型物对果蝇（果蝇）和蚊子（四斑按蚊）显示出相似的致死率，最不稳定的多晶型物显示出稍高的致死率。类似的活动可能会与结构相似性一致。然而，击倒动力学取决于内部代谢激活步骤，这进一步使多晶型依赖性生物利用度变得复杂。
更新日期：2024-01-17
中文翻译：
虫螨腈晶体多态性与杀虫活性
杀虫剂前体虫螨吡的四种结晶多晶型物 [4-溴-2-(4-氯苯基)-1-乙氧基甲基-5-三氟甲基-1 H-吡咯-3-甲腈]已通过偏光光学显微镜、差示扫描技术进行鉴定和表征量热法、拉曼光谱、X 射线衍射和电子衍射。四种结构中的三种被认为是多型的。氯芬那吡多晶型物对果蝇（果蝇）和蚊子（四斑按蚊）显示出相似的致死率，最不稳定的多晶型物显示出稍高的致死率。类似的活动可能会与结构相似性一致。然而，击倒动力学取决于内部代谢激活步骤，这进一步使多晶型依赖性生物利用度变得复杂。
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