The emergence of multi-drug-resistant bacteria is threatening to human health and life around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes fatal injuries to human beings and serious economic losses to animal husbandry due to its easy transmission and difficult treatment. Currently, the development of novel, highly effective, and low-toxicity antimicrobials is important to combat MRSA infections. Thiazole-containing compounds with good biological activity are widely used in clinical practice, and appropriate structural modifications make it possible to develop new antimicrobials. Here, we review thiazole-containing compounds and their antibacterial effects against MRSA reported in the past two decades and discuss their structure–activity relationships as well as the corresponding antimicrobial mechanisms. Some thiazole-containing compounds exhibit potent antibacterial efficacy in vitro and in vivo after appropriate structural modifications and could be used as antibacterial candidates. This Review provides insights into the development of thiazole-containing compounds as antimicrobials to combat MRSA infections.

中文翻译：

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含噻唑化合物作为抗甲氧西林金黄色葡萄球菌的潜在抗菌剂的最新进展

多重耐药细菌的出现正在威胁着全世界人类的健康和生命。特别是耐甲氧西林金黄色葡萄球菌（MRSA）因其传播容易、治疗困难，给人类造成致命伤害，给畜牧业带来严重的经济损失。目前，开发新型、高效、低毒的抗菌药物对于对抗 MRSA 感染非常重要。含噻唑类化合物具有良好的生物活性，广泛应用于临床，适当的结构修饰使得开发新型抗菌药物成为可能。在此，我们回顾了过去二十年报道的含噻唑类化合物及其对MRSA的抗菌作用，并讨论了它们的构效关系以及相应的抗菌机制。一些含噻唑化合物经过适当的结构修饰后在体外和体内表现出有效的抗菌功效，可用作抗菌候选物。本综述深入探讨了含噻唑化合物作为抗 MRSA 感染的抗菌剂的开发。