Dermal wounds are a major global health burden made worse by common comorbidities such as diabetes and infection. Appropriate wound closure relies on a highly coordinated series of cellular events, ultimately bridging tissue gaps and regenerating normal physiological structures. Wound dressings are an important component of wound care management, providing a barrier against external insults while preserving the active reparative processes underway within the wound bed. The development of wound dressings with biomaterial constituents has become an attractive design strategy due to the varied functions intrinsic in biological polymers, such as cell instructiveness, growth factor binding, antimicrobial properties, and tissue integration. Using photosensitive agents to generate crosslinked or photopolymerized dressings in situ provides an opportunity to develop dressings rapidly within the wound bed, facilitating robust adhesion to the wound bed for greater barrier protection and adaptation to irregular wound shapes. Despite the popularity of this fabrication approach, relatively few experimental wound dressings have undergone preclinical translation into animal models, limiting the overall integrity of assessing their potential as effective wound dressings. Here, we provide an up-to-date narrative review of reported photoinitiator- and wavelength-guided design strategies for in situ light activation of biomaterial dressings that have been evaluated in preclinical wound healing models.

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用于皮肤伤口愈合和修复的原位光激活材料：叙述性评论

皮肤伤口是全球主要的健康负担，糖尿病和感染等常见合并症使情况变得更加严重。适当的伤口闭合依赖于一系列高度协调的细胞事件，最终弥合组织间隙并再生正常的生理结构。伤口敷料是伤口护理管理的重要组成部分，提供抵御外部损伤的屏障，同时保持伤口床内正在进行的积极修复过程。由于生物聚合物固有的多种功能，例如细胞指导性、生长因子结合、抗菌特性和组织整合，使用生物材料成分开发伤口敷料已成为一种有吸引力的设计策略。使用光敏剂原位生成交联或光聚合敷料提供了在伤口床内快速形成敷料的机会，促进与伤口床的牢固粘附，以提供更好的屏障保护并适应不规则的伤口形状。尽管这种制造方法很受欢迎，但相对较少的实验性伤口敷料经过临床前转化为动物模型，限制了评估其作为有效伤口敷料的潜力的整体完整性。在这里，我们对已报道的生物材料敷料原位光激活的光引发剂和波长引导设计策略进行了最新的叙述性评论，这些策略已在临床前伤口愈合模型中进行了评估。