<br>PD-Ballet 研究：一项随机对照单盲混合 2 型临床试验的研究方案，评估芭蕾舞对帕金森病运动和非运动症状的影响,BMC Complementary Medicine and Therapies

当前位置： X-MOL 学术 › BMC Complementary Medicine and Therapies › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

PD-Ballet 研究：一项随机对照单盲混合 2 型临床试验的研究方案，评估芭蕾舞对帕金森病运动和非运动症状的影响
BMC Complementary Medicine and Therapies ( IF 3.3 ) Pub Date : 2024-01-17 , DOI: 10.1186/s12906-023-04296-y
Aleksandra M Podlewska _{1,

2} , Lucia Batzu _{1,

2} , Tayana Soukup ₃ , Nick Sevdalis ₄ , Ioannis Bakolis ₁ , Fleur Derbyshire-Fox ₅ , Alison Hartley ₅ , Andy Healey ₁ , Anthony Woods ₁ , Nikki Crane ₁ , Carmine Pariante ₁ , K Ray Chaudhuri _{1,

2}

Affiliation

摘要背景迄今为止，多模式运动计划对帕金森病 (PD) 的有益效果主要集中在运动症状上，而很少关注此类计划对 PD 非运动症状的潜在影响，目前，帕金森病被普遍称为一种非运动症状。生活质量的关键驱动因素和未满足的关键需求。我们的目标是探索基于芭蕾舞的舞蹈项目在解决帕金森病各个进展阶段的非运动和运动症状方面的临床效果。方法对 160 名帕金森病患者进行一项随机、单盲、对照试验，试验对象包括所有运动阶段（参与者将被分为三组运动进展：Hoehn 和 Yahr (HY) 阶段 I 和 II 为轻度组，HY 阶段 III 为中度组组和 HY 阶段 IV 和 V（即严重组）将使用独立的随机化机构随机分配到干预组或对照组。主要结果是根据运动障碍协会非运动量表（MDS-NMS）测量的非运动症状的改善。干预方案包括由英国国家芭蕾舞团主持的 12 场每周一次的舞蹈课程。每次会议之后都有“茶和饼干”社交时间。对照组遵循标准临床路径并加入“茶和饼干”以控制社交互动的任何积极影响。所有参与者均在基线、干预完成后以及 3-6 个月后接受评估，以探索任何潜在的纵向效应。讨论据我们所知，还没有足够有力的研究探讨基于舞蹈的干预对帕金森病非运动症状的影响，并在整体和细粒度层面上评估这些症状。我们还旨在根据评估的参与者的运动状态对参与者进行分层。 HY 分期旨在探索疾病初期、中期和复杂阶段症状的具体影响。如果成功，该试验将提供第一个证据，证明基于芭蕾舞的舞蹈干预对帕金森病症状的临床有效性，并以稳健、严格的方式进行评估。试用注册NCT04719468。

"点击查看英文标题和摘要"

The PD-Ballet study: study protocol for a randomised controlled single-blind hybrid type 2 clinical trial evaluating the effects of ballet dancing on motor and non-motor symptoms in Parkinson’s disease

Abstract Background To date, beneficial effects of multimodal exercise programmes on Parkinson’s disease (PD) have focused on motor symptoms and little attention has been paid to the potential effects of such programmes on the non-motor symptoms of PD, which are now universally known as one of the key drivers of quality of life and a key unmet need. We aim to explore clinical effectiveness of a ballet-based dance programme in addressing non-motor and motor symptoms of Parkinson’s disease across all stages of progression. Methods A randomised, single-blind, controlled trial of 160 people with Parkinson’s across all motor stages (Participants will be stratified into three groups of motor advancement: Hoehn and Yahr (HY) stages I and II being Mild Group, HY Stage III being Moderate Group and HY Stages IV and V being Severe Group) will be randomly allocated to either an intervention or a control group using an independent randomisation body. The primary outcome is an improvement in non-motor symptoms as measured by the Movement Disorders Society Non-Motor Scale (MDS-NMS). The intervention protocol consists of 12 one-weekly dance sessions led by English National Ballet. Each session is followed by a ‘tea and biscuit’ social time. Control group follows standard clinical pathway and joins the ‘tea and biscuit’ to control for any positive effects of social interactions. All participants are assessed at baseline, immediately after completion of the intervention and 3–6 months later to explore any potential longitudinal effects. Discussion To our knowledge, no adequately powered study has explored the effects of a dance-based intervention on non-motor symptoms of Parkinson’s disease, assessing these on both holistic and granular levels. We also aim to stratify participants in accordance with their motor state as assessed by. HY staging to explore specific effects on the symptoms at the initial, moderate and complex stages of the disease. If successful, this trial provides first evidence on clinical effectiveness of a ballet-based dance intervention for symptoms of Parkinson’s disease, assessed in a robust, rigorous manner. Trial registration NCT04719468.

更新日期：2024-01-17

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文

全部期刊列表>>