<br>具有增强微波吸收功能的磁性双金属异质界面纳米导弹用于乳腺癌的微波热/动力治疗,ACS Nano

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具有增强微波吸收功能的磁性双金属异质界面纳米导弹用于乳腺癌的微波热/动力治疗
ACS Nano ( IF 15.8 ) Pub Date : 2024-01-16 , DOI: 10.1021/acsnano.3c11433
Min Yu _{1,

2,

3} , Shimei Li _{1,

3} , Xiangling Ren _{1,

3} , Nan Liu _{1,

3} , Wenna Guo _{1,

3} , Jian Xue ₄ , Longfei Tan _{1,

3} , Changhui Fu _{1,

3} , Qiong Wu _{1,

3} , Meng Niu ₄ , Yongxing Du ₂ , Xianwei Meng _{1,

3}

Affiliation

微波热疗（MWT）由于其深层组织穿透性和微创性，在癌症治疗中显示出巨大的潜力。然而，微波热敏剂在医用频段内较差的微波吸收（MA）特性极大地限制了MWT的热效应，从而削弱了治疗效果。在本文中，开发了一种基于 MOFs-Ni-Ru@COFs (MNRC) 的镍基多层异质界面纳米导弹，通过引入磁损耗和介电损耗，在所需频段改善了 MA 性能，用于基于 MWT 的处理。 MNRC 中 Ni 纳米颗粒的负载介导了磁损耗，将 MA 引入医疗频段。通过纳米工程在 MNRC 中形成的异质界面会引起显着的界面极化，增加介电损耗，从而增强生成的 MA 性能。此外，MNRC在所需频率范围内具有强大的MA性能，不仅增强了MWT的MW热效应，而且还促进电子和能量转移，在肿瘤部位产生活性氧（ROS）以介导微波动态治疗（MDT）。通过强化敏化剂在医用频段的MA性能来提高MWT-MDT的策略，为扩大MWT在肿瘤治疗中的临床应用提供了方向。

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Magnetic Bimetallic Heterointerface Nanomissiles with Enhanced Microwave Absorption for Microwave Thermal/Dynamics Therapy of Breast Cancer

Microwave thermotherapy (MWT) has shown great potential in cancer treatment due to its deep tissue penetration and minimally invasive nature. However, the poor microwave absorption (MA) properties of the microwave thermal sensitizer in the medical frequency band significantly limit the thermal effect of MWT and then weaken the therapeutic efficacy. In this paper, a Ni-based multilayer heterointerface nanomissile of MOFs-Ni-Ru@COFs (MNRC) with improved MA performance in the desired frequency band via introducing magnetic loss and dielectric loss is developed for MWT-based treatment. The loading of the Ni nanoparticle in MNRC mediates the magnetic loss, introducing the MA in the medical frequency band. The heterointerface formed in the MNRC by nanoengineering induces significant interfacial polarization, increasing the dielectric loss and then enhancing the generated MA performance. Moreover, MNRC with the strong MA performance in the desired frequency range not only enhances the MW thermal effect of MWT but also facilitates the electron and energy transfer, generating reactive oxygen species (ROS) at tumor sites to mediate microwave dynamic therapy (MDT). The strategy of strengthening the MA performance of the sensitizer in the medical frequency band to improve MWT-MDT provides a direction for expanding the clinical application of MWT in tumor treatment.

更新日期：2024-01-16

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