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Flexible, scalable, high channel count stereo-electrode for recording in the human brain
Nature Communications ( IF 14.7 ) Pub Date : 2024-01-17 , DOI: 10.1038/s41467-023-43727-9
Keundong Lee 1 , Angelique C Paulk 2, 3 , Yun Goo Ro 1 , Daniel R Cleary 1, 4 , Karen J Tonsfeldt 1, 5 , Yoav Kfir 6, 7 , John S Pezaris 6, 7 , Youngbin Tchoe 1 , Jihwan Lee 1 , Andrew M Bourhis 1 , Ritwik Vatsyayan 1 , Joel R Martin 1 , Samantha M Russman 1 , Jimmy C Yang 6, 7 , Amy Baohan 6, 7 , R Mark Richardson 6, 7 , Ziv M Williams 6, 7 , Shelley I Fried 6, 7 , U Hoi Sang 1 , Ahmed M Raslan 8 , Sharona Ben-Haim 4 , Eric Halgren 9 , Sydney S Cash 2, 3 , Shadi A Dayeh 1
Affiliation  

Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.



中文翻译:


灵活、可扩展、高通道数立体电极,用于在人脑中进行记录



在过去的十年中,立体定向放置的电极已成为多种神经和精神疾病的深部脑记录和刺激的黄金标准。然而,当前的电极在空间分辨率和记录小群神经元的能力方面受到限制,更不用说单个神经元了。在这里,我们报告了一种创新的、可定制的、单片集成的人类级柔性深度电极,能够记录多达 128 个通道,并且能够在脑组织中记录 10 厘米的深度。这种薄型、探针引导的深度电极能够记录局部场电位和单个单元神经元活动(动作电位),并经过跨物种验证。该设备代表了制造和设计方法的进步,扩展了临床神经病学主流技术的能力。

更新日期:2024-01-17
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