Carbomer Hydrogel Composed of Cu2O and Hematoporphyrin Monomethyl Ether Promotes the Healing of Infected Wounds,ACS Omega

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Carbomer Hydrogel Composed of Cu2O and Hematoporphyrin Monomethyl Ether Promotes the Healing of Infected Wounds
ACS Omega ( IF 3.7 ) Pub Date : 2024-01-16 , DOI: 10.1021/acsomega.3c08718
Dongyu Wang _{1,

2} , Jiale Jin ₂ , Chengran Zhang ₁ , Chengxin Ruan ₂ , Yifang Qin ₃ , Dongdong Li ₄ , Ming Guan _{2,

5,

6} , Pengfei Lei ₂

Affiliation

Infectious wounds pose a significant challenge in the field of wound healing primarily due to persistent inflammation and the emergence of antibiotic-resistant bacteria. To combat these issues, the development of an effective wound dressing that can prevent infection and promote healing is of the utmost importance. Photodynamic therapy (PDT) has emerged as a promising noninvasive treatment strategy for tackling antibiotic-resistant bacteria. A biodegradable photosensitizer called hematoporphyrin monomethyl ether (HMME) has shown potential in generating reactive oxygen species (ROS) upon laser activation to combat bacteria. However, the insolubility of HMME limits its antibacterial efficacy and its ability to facilitate skin healing. To overcome these limitations, we have synthesized a compound hydrogel by combining carbomer, HMME, and Cu₂O nanoparticles. This compound hydrogel exhibits enhanced antimicrobial ability and excellent biocompatibility and promotes angiogenesis, which is crucial for the healing of skin defects. By integrating the benefits of HMME, Cu₂O nanoparticles, and the gel-forming properties of carbomer, this compound hydrogel shows great potential as an effective wound dressing material. In summary, the compound hydrogel developed in this study offers a promising solution for infectious wounds by addressing the challenges of infection prevention and promoting skin healing. This innovative approach utilizing PDT and the unique properties of the compound hydrogel could significantly improve the outcomes of wound healing in clinical settings.

中文翻译：

由 Cu2O 和血卟啉单甲醚组成的卡波姆水凝胶促进感染伤口愈合

感染性伤口在伤口愈合领域提出了重大挑战，主要是由于持续的炎症和抗生素耐药细菌的出现。为了解决这些问题，开发一种可以预防感染并促进愈合的有效伤口敷料至关重要。光动力疗法（PDT）已成为一种有前途的对抗抗生素耐药细菌的非侵入性治疗策略。一种名为血卟啉单甲醚 (HMME) 的可生物降解光敏剂显示出在激光激活后产生活性氧 (ROS) 来对抗细菌的潜力。然而，HMME 的不溶性限制了其抗菌功效及其促进皮肤愈合的能力。为了克服这些限制，我们通过结合卡波姆、HMME 和 Cu ₂ O 纳米颗粒合成了一种复合水凝胶。这种复合水凝胶具有增强的抗菌能力和优异的生物相容性，并能促进血管生成，这对皮肤缺损的愈合至关重要。通过整合HMME、Cu ₂ O纳米粒子和卡波姆的凝胶形成特性的优点，这种复合水凝胶显示出作为有效伤口敷料材料的巨大潜力。总之，本研究开发的复合水凝胶通过解决感染预防和促进皮肤愈合的挑战，为感染性伤口提供了一种有前景的解决方案。这种利用 PDT 和复合水凝胶独特特性的创新方法可以显着改善临床环境中伤口愈合的结果。

更新日期：2024-01-16

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