Continuous Flow Synthesis of 4-methyl-3-oxo-n-phenyl-pentanamide,ChemistrySelect

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Continuous Flow Synthesis of 4-methyl-3-oxo-n-phenyl-pentanamide
ChemistrySelect ( IF 1.9 ) Pub Date : 2024-01-16 , DOI: 10.1002/slct.202304182
Yiguo He ₁ , Mengxiang Li ₁ , Liming Peng ₁ , Tong Yang ₂ , Dong Zhang ₃ , Yadong Zhang ₁

Affiliation

Atorvastatin calcium is a pivotal pharmaceutical for the treatment of primary hypercholesterolemia, with the reaction between isobutyl acetate and aniline being a crucial step. By employing continuous flow synthesis technology, we achieved a yield of 94 % within a residence time of 15 minutes. Simultaneously, kinetic studies and CFD calculations were conducted. Subsequently, we conducted further reaction investigations and designed a continuous system.

中文翻译：

4-甲基-3-氧代-n-苯基-戊酰胺的连续流合成

阿托伐他汀钙是治疗原发性高胆固醇血症的关键药物，其中乙酸异丁酯与苯胺之间的反应是关键步骤。通过采用连续流合成技术，我们在 15 分钟的停留时间内实现了 94% 的产率。同时进行了动力学研究和CFD计算。随后，我们进行了进一步的反应研究并设计了连续系统。

更新日期：2024-01-17

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