Atorvastatin calcium is a pivotal pharmaceutical for the treatment of primary hypercholesterolemia, with the reaction between isobutyl acetate and aniline being a crucial step. By employing continuous flow synthesis technology, we achieved a yield of 94 % within a residence time of 15 minutes. Simultaneously, kinetic studies and CFD calculations were conducted. Subsequently, we conducted further reaction investigations and designed a continuous system.

中文翻译：

---

4-甲基-3-氧代-n-苯基-戊酰胺的连续流合成

阿托伐他汀钙是治疗原发性高胆固醇血症的关键药物，其中乙酸异丁酯与苯胺之间的反应是关键步骤。通过采用连续流合成技术，我们在 15 分钟的停留时间内实现了 94% 的产率。同时进行了动力学研究和CFD计算。随后，我们进行了进一步的反应研究并设计了连续系统。