先进纳米酶在生物医学和抗菌领域具有类过氧化物酶催化活性：回顾与进展,Nanoscale

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先进纳米酶在生物医学和抗菌领域具有类过氧化物酶催化活性：回顾与进展
Nanoscale ( IF 5.8 ) Pub Date : 2024-01-12 , DOI: 10.1039/d3nr05592b
Yunxin Ye _{1,

2} , Jiyuan Zou _{1,

2} , Weian Wu _{1,

2} , Ziyan Wang _{1,

2} , Siyi Wen _{1,

2} , Zitian Liang _{1,

2} , Shirong Liu _{1,

2} , Yifan Lin _{1,

2} , Xuanyu Chen _{1,

2} , Tao Luo _{1,

2} , Li Yang _{1,

2} , Qianzhou Jiang _{1,

2} , Lvhua Guo _{1,

2}

Affiliation

由细菌入侵引起的传染病给全球带来了巨大的健康和经济负担。更令人担忧的是，滥用抗生素下诞生的多重耐药（MDR）致病菌让现状进一步升级。如今，在化学、纳米科学和生物医学等多个学科的交叉口，纳米酶作为类酶纳米材料，不仅具有优异的杀菌能力，而且降低了诱发耐药性的可能性。因此，纳米酶有望成为传统抗生素的替代品。模拟过氧化物酶（POD）活性的纳米酶也称为POD纳米酶。近年来，POD纳米酶因其广谱杀菌特性和独特的杀菌机制而成为最常报道、最有效的纳米酶之一。在这篇综述中，我们介绍了 POD 纳米酶的作用机制以及分类。更重要的是，为了进一步提高POD纳米酶的抗菌功效，我们从三个方面进行了阐述：（1）改善理化性质；(2)调节催化微环境；(3)设计多模型POD纳米酶。此外，我们回顾了 POD 纳米酶的纳米安全性，讨论了它们的潜在毒性。最后，讨论了 POD 纳米酶的剩余挑战和未来可能的方向。本工作对POD纳米酶进行了系统总结，希望能为早期临床转化做出贡献。

"点击查看英文标题和摘要"

Advanced nanozymes possess peroxidase-like catalytic activities in biomedical and antibacterial fields: review and progress

Infectious diseases caused by bacterial invasions have imposed a significant global health and economic burden. More worryingly, multidrug-resistant (MDR) pathogenic bacteria born under the abuse of antibiotics have further escalated the status quo. Nowadays, at the crossroads of multiple disciplines such as chemistry, nanoscience and biomedicine, nanozymes, as enzyme-mimicking nanomaterials, not only possess excellent bactericidal ability but also reduce the possibility of inducing resistance. Thus, nanozymes are promising to serve as an alternative to traditional antibiotics. Nanozymes that mimic peroxidase (POD) activity are also known as POD nanozymes. In recent years, POD nanozymes have become one of the most frequently reported and effective nanozymes due to their broad-spectrum bactericidal properties and unique sterilization mechanism. In this review, we introduce the mechanism as well as the classification of POD nanozymes. More importantly, to further improve the antibacterial efficacy of POD nanozymes, we elaborate on three aspects: (1) improving the physicochemical properties; (2) regulating the catalytic microenvironment; and (3) designing multimodel POD nanozymes. In addition, we review the nanosafety of POD nanozymes for discussing their potential toxicity. Finally, the remaining challenges of POD nanozymes and possible future directions are discussed. This work provides a systematic summary of POD nanozymes and hopefully contributes to the early clinical translation.

更新日期：2024-01-12

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