Discovery of matrix metalloproteinase inhibitors as anti-skin photoaging agents,European Journal of Medicinal Chemistry

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Discovery of matrix metalloproteinase inhibitors as anti-skin photoaging agents
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2024-01-14 , DOI: 10.1016/j.ejmech.2024.116152
Feifan Li ₁ , Jia Zhi ₁ , Rui Zhao ₁ , Yinyan Sun ₁ , Hao Wen ₁ , Hong Cai ₁ , Wenchao Chen ₁ , Xiaoying Jiang ₁ , Renren Bai ₁

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Photodamage is the result of prolonged exposure of the skin to sunlight. This exposure causes an overexpression of matrix metalloproteinases (MMPs), leading to the abnormal degradation of collagen in the skin tissue and resulting in skin aging and damage. This review presents a detailed overview of MMPs as a potential target for addressing skin aging. Specifically, we elucidated the precise mechanisms by which MMP inhibitors exert their anti-photoaging effects. Furthermore, we comprehensively analyzed the current research progress on MMP inhibitors that demonstrate significant inhibitory activity against MMPs and anti-skin photoaging effects. The review also provides insights into the structure-activity relationships of these inhibitors. Our objective in conducting this review is to provide valuable practical information to researchers engaged in investigations on anti-skin photoaging.

中文翻译：

发现基质金属蛋白酶抑制剂作为抗皮肤光老化剂

光损伤是皮肤长时间暴露在阳光下的结果。这种暴露会导致基质金属蛋白酶（MMP）过度表达，导致皮肤组织中胶原蛋白的异常降解，从而导致皮肤老化和损伤。这篇综述详细概述了 MMP 作为解决皮肤衰老问题的潜在目标。具体来说，我们阐明了 MMP 抑制剂发挥抗光老化作用的精确机制。此外，我们还全面分析了目前MMP抑制剂的研究进展，这些抑制剂显示出显着的MMP抑制活性和抗皮肤光老化作用。该综述还提供了对这些抑制剂的结构-活性关系的见解。我们进行本次综述的目的是为从事抗皮肤光老化研究的研究人员提供有价值的实用信息。

更新日期：2024-01-14

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