AMPA receptor neurotransmission and therapeutic applications: A comprehensive review of their multifaceted modulation,European Journal of Medicinal Chemistry

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AMPA receptor neurotransmission and therapeutic applications: A comprehensive review of their multifaceted modulation
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2024-01-14 , DOI: 10.1016/j.ejmech.2024.116151
Mohammad Qneibi ₁ , Sosana Bdir ₁ , Mohammad Bdair ₁ , Samia Ammar Aldwaik ₁ , Dana Sandouka ₁ , Maram Heeh ₂ , Tala Iyad Idais ₁

Affiliation

The neuropharmacological community has shown a strong interest in AMPA receptors as critical components of excitatory synaptic transmission during the last fifteen years. AMPA receptors, members of the ionotropic glutamate receptor family, allow rapid excitatory neurotransmission in the brain. AMPA receptors, which are permeable to sodium and potassium ions, manage the bulk of the brain's rapid synaptic communications. This study thoroughly examines the recent developments in AMPA receptor regulation, focusing on a shift from single chemical illustrations to a more extensive investigation of underlying processes. The complex interplay of these modulators in modifying the function and structure of AMPA receptors is the main focus, providing insight into their influence on the speed of excitatory neurotransmission. This research emphasizes the potential of AMPA receptor modulation as a therapy for various neurological disorders such as epilepsy and Alzheimer's disease. Analyzing these regulators' sophisticated molecular details enhances our comprehension of neuropharmacology, representing a significant advancement in using AMPA receptors for treating intricate neurological conditions.

中文翻译：

AMPA 受体神经传递和治疗应用：对其多方面调节的全面回顾

在过去 15 年里，神经药理学界对 AMPA 受体作为兴奋性突触传递的关键成分表现出了浓厚的兴趣。 AMPA 受体是离子型谷氨酸受体家族的成员，可在大脑中实现快速的兴奋性神经传递。 AMPA 受体可渗透钠离子和钾离子，负责管理大脑的大部分快速突触通讯。这项研究彻底考察了 AMPA 受体调节的最新进展，重点关注从单一化学插图到对潜在过程进行更广泛研究的转变。这些调节剂在改变 AMPA 受体功能和结构方面的复杂相互作用是主要焦点，有助于深入了解它们对兴奋性神经传递速度的影响。这项研究强调了 AMPA 受体调节作为治疗癫痫和阿尔茨海默病等各种神经系统疾病的潜力。分析这些调节因子复杂的分子细节可以增强我们对神经药理学的理解，代表着使用 AMPA 受体治疗复杂的神经系统疾病的重大进步。

更新日期：2024-01-14

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