类沸石 Ln-MOF 发光纳米传感器可高效检测 l-去甲肾上腺素,ACS Applied Nano Materials

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类沸石 Ln-MOF 发光纳米传感器可高效检测 l-去甲肾上腺素
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2024-01-13 , DOI: 10.1021/acsanm.3c05186
Xinhui Fang ₁ , Zeyi Jiang ₁ , Xueying Zhou ₁ , Jing Du ₂ , Yupeng Jiang ₁ , Di Wang ₁ , Xinrui Wang ₁ , Bin Ding ₁

Affiliation

l -去甲肾上腺素 ( l -NE) 是交感神经分支节后神经元释放的神经递质，刺激人体血液中l -NE 的分泌。准确监测血清中的l -NE浓度对于检测兴奋剂和防止竞技赛事中的欺诈至关重要。_{在本研究中，我们介绍了一种使用名为 Eu 0.479} Tb _0.521 -ZMOF的类沸石镧系金属有机骨架 (Ln-MOF)检测l -NE 的方法，该框架由 H ₂ bpdc 配体构建（其中 H ₂ bpdc代表2,2'-联吡啶-6,6'-二羧酸），并形成纳米棒。值得注意的是，与基于Ln-MOF的单次发射相比，比率发光探针Eu _0.479 Tb _0.521 -ZMOF表现出卓越的传感性能，能够高效检测各种抗抑郁激素中的l -NE。l -NE的检测限 (LOD)为 129 μM。此外，Eu _0.479 Tb _0.521 -ZMOF 已被合成为纳米棒，可促进人血清溶液中l -NE 的有效检测，表现出令人印象深刻的回收率，范围为 97.5 至 100%。此外，还成功开发了一种源自Eu _0.479 Tb _0.521 -ZMOF的发光膜，并用于l -NE的视觉检测。总之，我们的研究全面阐明了基于类沸石Ln-MOFs Eu _0.479 Tb _0.521 -ZMOF的l -NE的详细检测机制。

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Zeolite-Like Ln-MOF Luminescent Nanosensor for Highly Efficient Detection of l-Noradrenaline

l-Noradrenaline (l-NE) is a neurotransmitter released by postganglionic neurons in the sympathetic nerve branch and stimulates the secretion of l-NE in human blood. Accurate monitoring of the l-NE concentration in serum is crucial for detecting stimulants and preventing fraud in competitive events. In this study, we introduce an approach for the detection of l-NE using a zeolite-like lanthanide metal–organic framework (Ln-MOF) named Eu_0.479Tb_0.521-ZMOF, constructed with a H₂bpdc ligand (where H₂bpdc stands for 2,2′-bipyridine-6,6′-dicarboxylate acid), and forming a nanorod. Notably, the ratiometric luminescent probe Eu_0.479Tb_0.521-ZMOF showcases superior sensing performance compared to single emission based on Ln-MOF, enabling highly efficient detection of l-NE among various antidepressant hormones. The limit of detection (LOD) for l-NE was 129 μM. Additionally, Eu_0.479Tb_0.521-ZMOF has been synthesized into nanorods, which promote effective detection of l-NE in human serum solutions, exhibiting an impressive recovery rate ranging from 97.5 to 100%. Additionally, a luminescent membrane, derived from Eu_0.479Tb_0.521-ZMOF, was successfully developed and utilized for visual detection of l-NE. In conclusion, our study comprehensively elucidates the detailed detection mechanism for l-NE based on zeolite-Like Ln-MOFs Eu_0.479Tb_0.521-ZMOF.

更新日期：2024-01-13

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