A potential trade-off between offense and defense in honeybee innate immunity: Reduced phagocytosis in honeybee hemocytes correlates with a protective response after exposure to imidacloprid and amitraz,Pesticide Biochemistry and Physiology

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A potential trade-off between offense and defense in honeybee innate immunity: Reduced phagocytosis in honeybee hemocytes correlates with a protective response after exposure to imidacloprid and amitraz
Pesticide Biochemistry and Physiology ( IF 4.2 ) Pub Date : 2024-01-14 , DOI: 10.1016/j.pestbp.2024.105772
Dani Sukkar ₁ , Philippe Laval-Gilly ₂ , Ali Kanso ₃ , Sabine Azoury ₄ , Antoine Bonnefoy ₅ , Jairo Falla-Angel ₂

Affiliation

Phagocytosis “offense” is a crucial process to protect the organism from diseases and the effects of foreign particles. Insects rely on the innate immune system and thus any hindrance to phagocytosis may greatly affect their resistance to diseases and response to pathogens. The European honeybee, a valuable species due to its economic and environmental contribution, is being challenged by colony collapse disorder leading to its decline. Exposure to multiple factors including pesticides like imidacloprid and amitraz may negatively alter their immune response and ultimately make them more susceptible to diseases. In this study, we compare the effect of different concentrations and mixtures of imidacloprid and amitraz with different concentrations of the immune stimulant, zymosan A. Results show that imidacloprid and amitraz have a synergistic negative effect on phagocytosis. The lowered phagocytosis induces significantly higher hemocyte viability suggesting a negatively correlated protective mechanism “defense” from pesticide-associated damage but may not be protective from pathogens.

中文翻译：

蜜蜂先天免疫进攻和防御之间的潜在权衡：蜜蜂血细胞吞噬作用的减少与暴露于吡虫啉和双甲脒后的保护性反应相关

吞噬作用“进攻”是保护生物体免受疾病和外来颗粒影响的关键过程。昆虫依赖先天免疫系统，因此吞噬作用的任何障碍都可能极大地影响它们对疾病的抵抗力和对病原体的反应。欧洲蜜蜂因其经济和环境贡献而成为一种有价值的物种，但它正面临着导致其衰退的蜂群崩溃失调的挑战。接触多种因素，包括吡虫啉和双甲脒等农药，可能会对他们的免疫反应产生负面影响，最终使他们更容易感染疾病。在本研究中，我们比较了不同浓度的吡虫啉和双甲脒以及不同浓度的免疫刺激剂酵母聚糖A的混合物的效果。结果表明，吡虫啉和双甲脒对吞噬作用具有协同负面作用。吞噬作用降低会导致血细胞活力显着升高，这表明负相关的保护机制“防御”农药相关的损害，但可能无法抵御病原体。

更新日期：2024-01-14

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