An environmentally friendly, clean, and applicable methodology for synthesizing 1,3-Thiazolidin-4-one derivatives was developed. This method produced the target compounds in high yields and short reaction times by using solvent-free reaction conditions with heterogeneous catalysts, montmorillonite (MT) and acid-activated montmorillonite (acid-MT). MT and acid-MT were investigated in the synthesis using a variety of techniques, including conventional heat, ultrasonic, and microwave irradiation, with the investigation of two types of factors, namely time and temperature. X-ray diffraction, N₂ adsorption–desorption, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy were used to characterize the MT and acid-MT catalysts. FTIR, ¹H NMR, ¹³C NMR, and mass spectra were used to characterize each product. The ring-cyclization step, with its short time and high yield percentage, is the most important factor for the strength of the prepared catalyst, acid-MT. Additionally, the acid-MT catalyst was easily recoverable and can be reused up to five times without suffering a substantial reduction in catalytic activity.

开发了一种环保、清洁、适用的1,3-噻唑烷-4-酮衍生物的合成方法。该方法采用无溶剂反应条件，采用非均相催化剂蒙脱石（MT）和酸活化蒙脱石（acid-MT），以高收率和短反应时间制备了目标化合物。使用多种技术（包括常规加热、超声波和微波辐射）对 MT 和酸-MT 的合成进行了研究，并研究了时间和温度两类因素。采用X射线衍射、N ₂吸附-脱附、傅里叶变换红外光谱、扫描电子显微镜和透射电子显微镜对MT和酸-MT催化剂进行了表征。使用FTIR、¹ H NMR、^{13 C NMR 和质谱来表征每种产物。}环化步骤时间短、收率高，是影响所制备的催化剂acid-MT强度的最重要因素。此外，酸-MT催化剂易于回收，可重复使用多达五次，而催化活性不会大幅降低。