Accurate detection of saliva glucose levels is crucail for diagnosing diabetes and oral diseases. However, the complex bacterial environment in the oral cavity presents challenges, particularly in reducing sensor sensitivity due to bacterial adhesion. The excellent self-cleaning capabilities of super-hydrophilic materials make them one of the top choices. To surpass the limitations of traditional super-hydrophilic materials, a Spin coating-Plasma treatment-Coprecipitation treatment (SPC) strategy was implemented to develop a super-hydrophilic gel saliva glucose sensor. Surface-initiated polymerization was used to form phenylboric acid hydrogels for glucose binding. A spin-coated transition layer protects the hydrogel, while plasma treatment and co-precipitation methods create a super-hydrophilic surface, providing antibacterial properties. The sensor demonstrated a remarkable ability to reduced bacterial adhesion of the five oral pathogenic bacteria by over 95 %, and significantly inhibited biofilm formation of and by 95.7 % and 96.7 %, respectively. Its detection limit of 3.04 mg/L meets the requirements for saliva glucose detection. Overall, the development of this super-hydrophilic gel sensor holds great promise for wearable oral monitoring devices, offering new opportunities in healthcare managing and monitoring.

中文翻译：

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用于唾液葡萄糖监测的抗生物膜超亲水凝胶传感器

准确检测唾液葡萄糖水平是诊断糖尿病和口腔疾病的关键。然而，口腔中复杂的细菌环境带来了挑战，特别是由于细菌粘附而降低了传感器的灵敏度。超亲水材料优异的自洁能力使其成为首选之一。为了超越传统超亲水材料的局限性，采用旋涂-等离子体处理-共沉淀处理（SPC）策略开发超亲水凝胶唾液葡萄糖传感器。使用表面引发聚合形成用于葡萄糖结合的苯基硼酸水凝胶。旋涂过渡层可保护水凝胶，而等离子体处理和共沉淀方法可形成超亲水表面，提供抗菌特性。该传感器表现出显着的能力，可将五种口腔致病菌的细菌粘附减少超过95%，并显着抑制生物膜形成，分别抑制95.7%和96.7%。其检出限为3.04 mg/L，满足唾液葡萄糖检测要求。总体而言，这种超亲水凝胶传感器的开发为可穿戴口腔监测设备带来了巨大的希望，为医疗保健管理和监测提供了新的机遇。