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Exploring Brilliant Blue FCF Assembly with Beta Cyclodextrin, Characterizations and Applications in Biological Systems Using Physicochemical and Computational Methods
ChemistrySelect ( IF 1.9 ) Pub Date : 2024-01-11 , DOI: 10.1002/slct.202302895 Baishali Saha 1 , Sanjoy Barman 1 , Modhusudan Mondal 1 , Subhankar Choudhury 2 , Subhadeep Saha 3 , Pranish Bomzan 4 , Salim Ali 1 , Kangkan Mallick 1 , Ankita Dutta 5 , Anoop Kumar 5 , Sanyukta Bhattacharjee 6 , Mahendra Nath Roy 1
ChemistrySelect ( IF 1.9 ) Pub Date : 2024-01-11 , DOI: 10.1002/slct.202302895 Baishali Saha 1 , Sanjoy Barman 1 , Modhusudan Mondal 1 , Subhankar Choudhury 2 , Subhadeep Saha 3 , Pranish Bomzan 4 , Salim Ali 1 , Kangkan Mallick 1 , Ankita Dutta 5 , Anoop Kumar 5 , Sanyukta Bhattacharjee 6 , Mahendra Nath Roy 1
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BrilliantBlue FCF dye is encapsulated within the nano hydrophobic cavity of β-cyclodextrin in aqueous medium and the inclusion complex formation is confirmed by various spectroscopic and physicochemical techniques. CT-DNA binding interaction study reveals the controlled release of dye from the complex. The complex shows enhanced photostability and expresses pronounced in vitrocytotoxic activity towards cancer cell line A549 comparison to pure dye.
中文翻译:
使用物理化学和计算方法探索亮蓝 FCF 与 β 环糊精的组装、表征及其在生物系统中的应用
BrilliantBlue FCF 染料被封装在水介质中 β-环糊精的纳米疏水空腔内,并且通过各种光谱和物理化学技术证实了包合物的形成。CT-DNA 结合相互作用研究揭示了复合物中染料的受控释放。与纯染料相比,该复合物显示出增强的光稳定性,并对癌细胞系 A549 表现出显着的体外细胞毒活性。
更新日期:2024-01-13
中文翻译:
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使用物理化学和计算方法探索亮蓝 FCF 与 β 环糊精的组装、表征及其在生物系统中的应用
BrilliantBlue FCF 染料被封装在水介质中 β-环糊精的纳米疏水空腔内,并且通过各种光谱和物理化学技术证实了包合物的形成。CT-DNA 结合相互作用研究揭示了复合物中染料的受控释放。与纯染料相比,该复合物显示出增强的光稳定性,并对癌细胞系 A549 表现出显着的体外细胞毒活性。