Nucleic acid therapeutics have the potential to revolutionize the biopharmaceutical industry, providing highly effective vaccines and novel treatments for cancers and genetic disorders. The successful commercialization of these therapeutics will require development of manufacturing strategies specifically tailored to the purification of nucleic acids. Membrane technologies already play a critical role in the downstream processing of nucleic acid therapeutics, ranging from clarification to concentration to selective purification. This review provides an overview of how membrane systems are currently used for nucleic acid purification, while highlighting areas of future need and opportunity, including adoption of membranes in continuous bioprocessing.

中文翻译：

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用于纯化 RNA 和 DNA 治疗药物的膜技术


核酸疗法有可能彻底改变生物制药行业，为癌症和遗传性疾病提供高效的疫苗和新的治疗方法。这些疗法的成功商业化将需要开发专门针对核酸纯化的制造策略。膜技术已经在核酸治疗的下游加工中发挥着关键作用，从澄清到浓缩再到选择性纯化。本综述概述了膜系统目前如何用于核酸纯化，同时强调了未来需求和机遇的领域，包括在连续生物处理中采用膜。