The data on multicomponent methods of tetrahydro-4H-indol-4-one synthesis published over the past ten years are summarized in this review. Three main synthetic approaches in the construction of such molecules are considered. Among them are: condensation of cyclohexane-1,3-diones with α-halogenoketones and primary amines, three-component reaction of cyclic enaminoketones, arylglyoxals, and methylene active compounds, and condensation of cyclic enaminoketones and arylglyoxals in the presence of nucleophilic reagents (often solvents). The latter domino reaction runs under microwave irradiation and leads to the functionalization of position 7 of the indole ring system. The material is systematized according to the structure of the starting compounds.

本综述总结了过去十年发表的四氢-4H-吲哚-4-酮多组分合成方法的数据。考虑了构建此类分子的三种主要合成方法。其中包括：环己烷-1,3-二酮与α-卤代酮和伯胺的缩合反应，环状烯胺酮、芳基乙二醛和亚甲基活性化合物的三组分反应，以及环状烯胺酮和芳基乙二醛在亲核试剂存在下的缩合反应（通常是溶剂）。后者的多米诺骨牌反应在微波辐射下进行并导致吲哚环系统的7位官能化。该材料根据起始化合物的结构进行系统化。