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Challenges and Opportunities of Using Fluorescent Metal Nanocluster-Based Colorimetric Assays in Medicine
ACS Omega ( IF 3.7 ) Pub Date : 2024-01-09 , DOI: 10.1021/acsomega.3c06884 Nasim Mohseni 1 , Mohammad Moodi 2 , Amirhosein Kefayat 1, 3 , Farhad Shokati 1 , Fatemeh Molaabasi 1
ACS Omega ( IF 3.7 ) Pub Date : 2024-01-09 , DOI: 10.1021/acsomega.3c06884 Nasim Mohseni 1 , Mohammad Moodi 2 , Amirhosein Kefayat 1, 3 , Farhad Shokati 1 , Fatemeh Molaabasi 1
Affiliation
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Development of rapid colorimetric methods based on novel optical-active metal nanomaterials has provided methods for the detection of ions, biomarkers, cancers, etc. Fluorescent metal nanoclusters (FMNCs) have gained a lot of attention due to their unique physical, chemical, and optical properties providing numerous applications from rapid and sensitive detection to cellular imaging. However, because of very small color changes, their colorimetric applications for developing rapid tests based on the naked eye or simple UV–vis absorption spectrophotometry are still limited. FMNCs with peroxidase-like activity have significant potential in a wide variety of applications, especially for point-of-care diagnostics. In this review, the effect of using various capping agents and metals for the preparation of nanoclusters in their colorimetric sensing properties is explored, and the synthesis and detection mechanisms and the recent advances in their application for ultrasensitive chemical and biological analysis regarding human health are highlighted. Finally, the challenges that remain as well as the future perspectives are briefly discussed. Overcoming these limitations will allow us to expand the nanocluster’s application for colorimetric diagnostic purposes in medical practice.
中文翻译：
在医学中使用基于荧光金属纳米簇的比色分析的挑战和机遇
基于新型光学活性金属纳米材料的快速比色法的开发为离子、生物标志物、癌症等的检测提供了方法。荧光金属纳米簇 （FMNC） 因其独特的物理、化学和光学特性而受到广泛关注，提供了从快速灵敏检测到细胞成像的众多应用。然而，由于颜色变化非常小，它们在开发基于肉眼或简单紫外-可见吸收分光光度法的快速测试的比色法应用仍然有限。具有过氧化物酶样活性的 FMNC 在各种应用中具有巨大的潜力，尤其是用于即时诊断。本文探讨了使用各种封端剂和金属制备纳米团簇的比色传感特性的影响，重点介绍了其合成和检测机制及其在人类健康超灵敏化学和生物分析中的应用进展。最后，简要讨论了仍然存在的挑战以及未来的前景。克服这些限制将使我们能够扩展纳米团簇在医疗实践中用于比色诊断目的的应用。
更新日期：2024-01-09
中文翻译：
在医学中使用基于荧光金属纳米簇的比色分析的挑战和机遇
基于新型光学活性金属纳米材料的快速比色法的开发为离子、生物标志物、癌症等的检测提供了方法。荧光金属纳米簇 （FMNC） 因其独特的物理、化学和光学特性而受到广泛关注，提供了从快速灵敏检测到细胞成像的众多应用。然而，由于颜色变化非常小，它们在开发基于肉眼或简单紫外-可见吸收分光光度法的快速测试的比色法应用仍然有限。具有过氧化物酶样活性的 FMNC 在各种应用中具有巨大的潜力，尤其是用于即时诊断。本文探讨了使用各种封端剂和金属制备纳米团簇的比色传感特性的影响，重点介绍了其合成和检测机制及其在人类健康超灵敏化学和生物分析中的应用进展。最后，简要讨论了仍然存在的挑战以及未来的前景。克服这些限制将使我们能够扩展纳米团簇在医疗实践中用于比色诊断目的的应用。
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