Abstract

A new copper(I) catalytic system has been developed for the alkyne–azide click reaction. 3,5-Dibenzylidene-1-(prop-2-yn-1-yl)piperidin-4-ones reacted with alkyl azides in water–tert-butyl alcohol (1:1) in the presence of a mixture of CuSO₄·5H₂O and sodium ascorbate to afford 3,5-dibenzylidene-1-(1-alkyl-1H-1,2,3-triazol-4-ylmethyl)piperidin-4-ones in good yields.

中文翻译：

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3,5-二亚苄基-1-(1-苄基-1H-1,2,3-三唑-4-基甲基)哌啶-4-酮的简便合成

摘要

一种用于炔烃-叠氮化物点击反应的新型铜（I）催化体系已被开发出来。3,5-二亚苄基-1-(丙-2-炔-1-基)哌啶-4-酮与烷基叠氮化物在水-叔丁醇(1:1)中在CuSO ₄混合物存在下反应5H ₂ O和抗坏血酸钠以良好的收率得到3,5-二亚苄基-1-(1-烷基-1H- 1,2,3-三唑-4-基甲基)哌啶-4-酮。