To compare treatment planning and dosimetric outcomes for hippocampal sparing whole brain radiotherapy (WBRT) with the simultaneous integrated boost (SIB) in brain metastasis (BM) patients using tumour control probability (TCP) and normal tissue complication probability (NTCP) formalism between IMRT, VMAT, and HT techniques. In this retrospective study, the treatment data of 20 BM patients who typically received whole brain radiation with SIB treatment were used. Prescription doses of 30 Gy and 36 Gy was delivered in 10 fractions for WBRT and SIB, respectively. Niemierko and LKB models were applied for calculating TCP and NTCP. All the plans were evaluated for the RTOG 0933 protocol criteria and found acceptable. Additionally, the homogeneity of the PTV boost is 0.07 ± 0.01, 0.1 ± 0.04, and 0.08 ± 0.02 for IMRT, VMAT, and HT, respectively (P < 0.05). The percentage of TCP for the PTV boost was 99.99 ± 0.003, 99.98 ± 0.004, and 99.99 ± 0.002 of IMRT, VMAT, and HT, respectively, (P < 0.005). The NTCP value of the lenses was higher with the VMAT plan as compared to IMRT and HT Plans. The hippocampal NTCP values are equal in all three planning proficiencies. The techniques like IMRT, VMAT, and HT can reduce the dose received by hippocampus to the dosimetric threshold during the delivery of WBRT with hippocampal sparing and can simultaneously boost multiple metastases. Overall, the high-quality dose distribution, TCP, and NTCP comparison between all three planning techniques show that the HT technique has better results when compared to the VMAT and IMRT techniques.

使用 IMRT 之间的肿瘤控制概率 (TCP) 和正常组织并发症概率 (NTCP) 形式，比较脑转移 (BM) 患者的海马保留全脑放疗 (WBRT) 与同步综合加强 (SIB) 的治疗计划和剂量测定结果， VMAT 和 HT 技术。在这项回顾性研究中，使用了 20 名通常接受全脑放疗和 SIB 治疗的 BM 患者的治疗数据。 WBRT 和 SIB 的处方剂量分别为 10 次，分别为 30 Gy 和 36 Gy。 Niemierko 和 LKB 模型用于计算 TCP 和 NTCP。所有计划都根据 RTOG 0933 协议标准进行了评估，并被认为是可接受的。此外，IMRT、VMAT 和 HT 的 PTV 增强均匀性分别为 0.07 ± 0.01、0.1 ± 0.04 和 0.08 ± 0.02 ( P < 0.05)。 IMRT、VMAT 和 HT 的 PTV 增强 TCP 百分比分别为 99.99 ± 0.003、99.98 ± 0.004 和 99.99 ± 0.002（ P < 0.005）。与 IMRT 和 HT 计划相比，VMAT 计划的镜片 NTCP 值更高。海马 NTCP 值在所有三种规划能力中都是相等的。 IMRT、VMAT 和 HT 等技术可以在保留海马的 WBRT 过程中将海马接受的剂量降低至剂量阈值，并可以同时促进多个转移。总体而言，所有三种计划技术之间的高质量剂量分布、TCP 和 NTCP 比较表明，与 VMAT 和 IMRT 技术相比，HT 技术具有更好的结果。