Inducing Rapid Cellular Response on RGD-Binding Threaded Macromolecular Surfaces,Journal of the American Chemical Society

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Inducing Rapid Cellular Response on RGD-Binding Threaded Macromolecular Surfaces
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2013-04-04 , DOI: 10.1021/ja400817q
Ji-Hun Seo _{1,

2} , Sachiro Kakinoki _{2,

3} , Yuuki Inoue _{2,

4} , Tetsuji Yamaoka _{2,

3} , Kazuhiko Ishihara _{2,

4} , Nobuhiko Yui _{1,

2}

Affiliation

The rapid response of integrin β1 molecules to an RGD peptide on a dynamic polyrotaxane surface was successfully induced. As a result, RGD peptides introduced on a highly dynamic cyclodextrin molecule enhanced the frequency of contact with specific integrin molecules on the cell membrane at the early stage of material-cell interactions.

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