Fitoterapia ( IF 2.5 ) Pub Date : 2024-01-09 , DOI: 10.1016/j.fitote.2024.105821 Xiong Qiu 1 , Yu Zhang 1 , Yao-Jun Xu 1 , Zhong-Dan Liang 1 , Xiao-Chang Dai 1 , Wei-Lie Xiao 1 , Xing-Jie Zhang 1 , Xiao-Li Li 1
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Four new diterpenoids (1–4) and four known diterpenoids (5–8) were purified from the whole plant of Euphorbia helioscopia L. Compounds 1 and 2 were jathophanes diterpenoids with a 5/12 polycyclic systems, compound 3 was rhamofolane diterpenoid with a 5/10 bicyclic skeleton and compound 4 was a rare class of euphorbia diterpenes featuring an unusual 5/10 fused ring system. Anti-inflammatory activity tests were conducted on the separated compounds, indicating that compound 4 had significant inhibitory effect on NLRP3 inflammasome with an IC50 value of 7.75 μM. Further, the inhibitory effect of 4 was determined using immunofluorescence assays.
中文翻译：
Euphzycopins A – D，大环二萜类化合物，来自大戟，具有潜在的抗炎活性
从大戟全草中纯化得到4 种新二萜 ( 1~4 ) 和 4 种已知二萜 ( 5~8 )。化合物1和2为具有 5/12 多环体系的麻黄烷二萜，化合物3为具有 5/12 多环体系的鼠李酚二萜。 5/10 双环骨架和化合物4是一类罕见的大戟二萜，具有不寻常的 5/10 稠合环系统。对分离的化合物进行抗炎活性测试，表明化合物4对NLRP3炎症小体具有显着的抑制作用，IC 50值为7.75 μM。此外，使用免疫荧光测定法测定4的抑制效果。
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